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Publications

Found 74 results
Author Title [ Type(Asc)] Year
Filters: Author is Schnappinger, Dirk  [Clear All Filters]
Journal Article
Beaulieu AM, Rath P, Imhof M, Siddall ME, Roberts J, Schnappinger D, Nathan CF.  2010.  Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.. PLoS One. 5(12):e15120.
Kim J-H, O'Brien KM, Sharma R, Boshoff HIM, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC et al..  2013.  A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.. Proc Natl Acad Sci U S A. 110(47):19095-100.
Schnappinger D.  2015.  Genetic Approaches to Facilitate Antibacterial Drug Development.. Cold Spring Harb Perspect Med. 5(7):a021139.
Dai R, Geders TW, Liu F, Park SWoong, Schnappinger D, Aldrich CC, Finzel BC.  2015.  Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.. J Med Chem. 58(13):5208-17.
Schnappinger D, Schoolnik GK, Ehrt S.  2006.  Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another.. Microbes Infect. 8(4):1132-40.
Park SWoong, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE, Aldrich CC et al..  2011.  Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.. PLoS Pathog. 7(9):e1002264.
Goodsmith N, Guo XV, Vandal OH, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P et al..  2015.  Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.. PLoS Pathog. 11(2):e1004645.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N et al..  2018.  Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.. J Med Chem. 61(22):9952-9965.
Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H et al..  2012.  Detection and treatment of subclinical tuberculosis.. Tuberculosis (Edinb). 92(6):447-52.
Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt S et al..  2020.  Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.. Mol Microbiol.
Wei J-R, Krishnamoorthy V, Murphy K, Kim J-H, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ.  2011.  Depletion of antibiotic targets has widely varying effects on growth.. Proc Natl Acad Sci U S A. 108(10):4176-81.
Botella L, Vaubourgeix J, Livny J, Schnappinger D.  2017.  Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.. Nat Commun. 8:14731.
Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D et al..  2013.  Database resources for the tuberculosis community.. Tuberculosis (Edinb). 93(1):12-7.
Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D.  2005.  Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.. Nucleic Acids Res. 33(2):e21.
Ehrt S, Schnappinger D.  2006.  Controlling gene expression in mycobacteria.. Future Microbiol. 1(2):177-84.
Schnappinger D, O'Brien KM, Ehrt S.  2015.  Construction of conditional knockdown mutants in mycobacteria.. Methods Mol Biol. 1285:151-75.
Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SWoong, Ioerger TR et al..  2017.  Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 61(12)
Rhee KY, de Carvalho LPedro Sori, Bryk R, Ehrt S, Marrero J, Park SWoong, Schnappinger D, Venugopal A, Nathan C.  2011.  Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.. Trends Microbiol. 19(7):307-14.
Schnappinger D, Ehrt S.  2016.  A broader spectrum of tuberculosis.. Nat Med. 22(10):1076-1077.
Shi C, Tiwari D, Wilson DJ, Seiler CL, Schnappinger D, Aldrich CC.  2013.  Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.. ACS Med Chem Lett. 4(12)
Duckworth BP, Geders TW, Tiwari D, Boshoff HI, Sibbald PA, Barry CE, Schnappinger D, Finzel BC, Aldrich CC.  2011.  Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.. Chem Biol. 18(11):1432-41.
Boshoff HIM, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park T-H, Yun C-S, Schnappinger D, Ehrt S et al..  2008.  Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.. J Biol Chem. 283(28):19329-41.
Morris RP, Nguyen L, Gatfield J, Visconti K, Nguyen K, Schnappinger D, Ehrt S, Liu Y, Heifets L, Pieters J et al..  2005.  Ancestral antibiotic resistance in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 102(34):12200-5.
Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S.  2009.  Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.. J Bacteriol. 191(2):625-31.