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photo of mosquito feeding on a human

Structural Study Points the Way to Better Malaria Drugs

Structural insights into a potent antimalarial drug candidate’s interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers at Weill Cornell Medicine and Van Andel Institute.

The antimalarial molecule, TDI-8304, is one of a new class of experimental therapeutics that targets the proteasome, an essential, multiprotein complex in P. falciparum...

tuberculosis affects the lungs

Weill Cornell Medicine Receives Grants for Tuberculosis Drug Development

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development. This effort will expediate finding new drug targets within the bacteria and identifying new lead compounds, two significant bottlenecks in TB drug development.

“These grants allow us to apply the assays we’ve developed in the last few years...

mosquito carrying malaria

New Findings Offer Insight into How Malaria Parasites Prepare for Transmission

A key developmental step in the lifecycle of the most virulent species of malaria parasite, Plasmodium falciparum, depends in part on a series of molecular signals that are detailed in a new study led by researchers at Weill Cornell Medicine. The findings may help scientists develop new ways to prevent malaria from spreading.

The parasites can spread from infected humans back to mosquitoes, completing their transmission cycle, only after they change from the asexual form that...

microscopic rendering

Research Reveals How a Common Bacterium May Spread from the Intestine

A typical gut bacterium that can spread through the body and cause a serious infection resists natural immune defenses and antibiotics by enhancing its protective outer layer, known as the cell envelope, according to a new study by Weill Cornell Medicine investigators. The finding suggests possible new ways to target these bacterial infections.

The research, published Nov. 10 in mBio, illuminates some of the underlying...

colocalization of extracellular DNA and CXCL4

Study Reveals New Mode of Triggering Immune Responses

Small proteins, called chemokines, that direct immune cells toward sites of infection can also form DNA-bound nanoparticles that can induce chronic, dysfunctional immune responses, according to a new study by researchers at Weill Cornell Medicine and Hospital for Special Surgery (HSS). The surprising discovery of this new activity for this well-studied class of immune signaling molecules could shed light on some types of immune...

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