For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit

Genetic Approaches to Facilitate Antibacterial Drug Development.

TitleGenetic Approaches to Facilitate Antibacterial Drug Development.
Publication TypeJournal Article
Year of Publication2015
AuthorsSchnappinger D
JournalCold Spring Harb Perspect Med
Date Published2015 Feb 13
KeywordsAntitubercular Agents, Drug Design, Humans, Mycobacterium tuberculosis, Tuberculosis

Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development.

Alternate JournalCold Spring Harb Perspect Med
PubMed ID25680982
PubMed Central IDPMC4484962

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587