Title | Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Schnappinger D, Schoolnik GK, Ehrt S |
Journal | Microbes Infect |
Volume | 8 |
Issue | 4 |
Pagination | 1132-40 |
Date Published | 2006 Apr |
ISSN | 1286-4579 |
Keywords | Animals, Humans, Macrophages, Mycobacterium tuberculosis, Nitric Oxide, Phagosomes, Reactive Oxygen Species, Receptors, Cell Surface, Signal Transduction, Species Specificity, Tuberculosis, Virulence |
Abstract | It has recently become feasible to quantify all mRNAs encoded by the genomes of bacterial pathogens and their eukaryotic host cells and to apply this approach to study the interaction of Mycobacterium tuberculosis with its primary host cell, the macrophage. These studies helped to identify regulatory circuits which mediate adaptation of the M. tuberculosis transcriptome to intraphagosomal environments and stimulated hypotheses for the function of these circuits in human tuberculosis. The macrophage transcriptome reacts to infections with the induction of a pathogen-unspecific expression program as well as the induction of pathogen-specific expression signatures, both of which contribute to the immunologic activation of the infected cell. M. tuberculosis induced changes in the macrophage transcriptome are mediated by Toll-like receptor dependent and Toll-like receptor independent signal transduction pathways. This response is shaped by macrophage produced reactive nitrogen and oxygen molecules and affected by viability and virulence of the pathogen. |
DOI | 10.1016/j.micinf.2005.10.027 |
Alternate Journal | Microbes Infect |
PubMed ID | 16517202 |
Grant List | R01AI44826 / AI / NIAID NIH HHS / United States R01AI57443 / AI / NIAID NIH HHS / United States R01HL68525 / HL / NHLBI NIH HHS / United States |
Submitted by jom4013 on December 3, 2020 - 3:27pm