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Schnappinger, Dirk
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G
Beaulieu AM
,
Rath P
,
Imhof M
,
Siddall ME
,
Roberts J
,
Schnappinger D
,
Nathan CF
. 2010.
Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.
.
PLoS One. 5(12):e15120.
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
Schnappinger D
. 2015.
Genetic Approaches to Facilitate Antibacterial Drug Development.
.
Cold Spring Harb Perspect Med. 5(7):a021139.
F
Dai R
,
Geders TW
,
Liu F
,
Park SWoong
,
Schnappinger D
,
Aldrich CC
,
Finzel BC
. 2015.
Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.
.
J Med Chem. 58(13):5208-17.
E
Schnappinger D
,
Schoolnik GK
,
Ehrt S
. 2006.
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another.
.
Microbes Infect. 8(4):1132-40.
Park SWoong
,
Klotzsche M
,
Wilson DJ
,
Boshoff HI
,
Eoh H
,
Manjunatha U
,
Blumenthal A
,
Rhee K
,
Barry CE
,
Aldrich CC
et al.
. 2011.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
.
PLoS Pathog. 7(9):e1002264.
D
Goodsmith N
,
Guo XV
,
Vandal OH
,
Vaubourgeix J
,
Wang R
,
Botella H
,
Song S
,
Bhatt K
,
Liba A
,
Salgame P
et al.
. 2015.
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
.
PLoS Pathog. 11(2):e1004645.
Oh S
,
Park Y
,
Engelhart CA
,
Wallach JB
,
Schnappinger D
,
Arora K
,
Manikkam M
,
Gac B
,
Wang H
,
Murgolo N
et al.
. 2018.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
.
J Med Chem. 61(22):9952-9965.
Robertson BD
,
Altmann D
,
Barry C
,
Bishai B
,
Cole S
,
Dick T
,
Duncan K
,
Dye C
,
Ehrt S
,
Esmail H
et al.
. 2012.
Detection and treatment of subclinical tuberculosis.
.
Tuberculosis (Edinb). 92(6):447-52.
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
Wei J-R
,
Krishnamoorthy V
,
Murphy K
,
Kim J-H
,
Schnappinger D
,
Alber T
,
Sassetti CM
,
Rhee KY
,
Rubin EJ
. 2011.
Depletion of antibiotic targets has widely varying effects on growth.
.
Proc Natl Acad Sci U S A. 108(10):4176-81.
Botella L
,
Vaubourgeix J
,
Livny J
,
Schnappinger D
. 2017.
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.
.
Nat Commun. 8:14731.
Lew JM
,
Mao C
,
Shukla M
,
Warren A
,
Will R
,
Kuznetsov D
,
Xenarios I
,
Robertson BD
,
Gordon SV
,
Schnappinger D
et al.
. 2013.
Database resources for the tuberculosis community.
.
Tuberculosis (Edinb). 93(1):12-7.
C
Ehrt S
,
Guo XV
,
Hickey CM
,
Ryou M
,
Monteleone M
,
Riley LW
,
Schnappinger D
. 2005.
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.
.
Nucleic Acids Res. 33(2):e21.
Ehrt S
,
Schnappinger D
. 2006.
Controlling gene expression in mycobacteria.
.
Future Microbiol. 1(2):177-84.
Schnappinger D
,
O'Brien KM
,
Ehrt S
. 2015.
Construction of conditional knockdown mutants in mycobacteria.
.
Methods Mol Biol. 1285:151-75.
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Rhee KY
,
de Carvalho LPedro Sori
,
Bryk R
,
Ehrt S
,
Marrero J
,
Park SWoong
,
Schnappinger D
,
Venugopal A
,
Nathan C
. 2011.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
.
Trends Microbiol. 19(7):307-14.
B
Schnappinger D
,
Ehrt S
. 2016.
A broader spectrum of tuberculosis.
.
Nat Med. 22(10):1076-1077.
Shi C
,
Tiwari D
,
Wilson DJ
,
Seiler CL
,
Schnappinger D
,
Aldrich CC
. 2013.
Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.
.
ACS Med Chem Lett. 4(12)
Duckworth BP
,
Geders TW
,
Tiwari D
,
Boshoff HI
,
Sibbald PA
,
Barry CE
,
Schnappinger D
,
Finzel BC
,
Aldrich CC
. 2011.
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
.
Chem Biol. 18(11):1432-41.
Boshoff HIM
,
Xu X
,
Tahlan K
,
Dowd CS
,
Pethe K
,
Camacho LR
,
Park T-H
,
Yun C-S
,
Schnappinger D
,
Ehrt S
et al.
. 2008.
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
.
J Biol Chem. 283(28):19329-41.
A
Morris RP
,
Nguyen L
,
Gatfield J
,
Visconti K
,
Nguyen K
,
Schnappinger D
,
Ehrt S
,
Liu Y
,
Heifets L
,
Pieters J
et al.
. 2005.
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 102(34):12200-5.
Vandal OH
,
Roberts JA
,
Odaira T
,
Schnappinger D
,
Nathan CF
,
Ehrt S
. 2009.
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
.
J Bacteriol. 191(2):625-31.
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