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Found 62 results
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Nathan, Carl
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1992
Xie QW
,
Cho HJ
,
Calaycay J
,
Mumford RA
,
Swiderek KM
,
Lee TD
,
Ding A
,
Troso T
,
Nathan C
. 1992.
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
.
Science. 256(5054):225-8.
1995
MacMicking JD
,
Nathan C
,
Hom G
,
Chartrain N
,
Fletcher DS
,
Trumbauer M
,
Stevens K
,
Xie QW
,
Sokol K
,
Hutchinson N
. 1995.
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.
.
Cell. 81(4):641-50.
1997
MacMicking JD
,
North RJ
,
LaCourse R
,
Mudgett JS
,
Shah SK
,
Nathan C
. 1997.
Identification of nitric oxide synthase as a protective locus against tuberculosis.
.
Proc Natl Acad Sci U S A. 94(10):5243-8.
2000
Bryk R
,
Griffin P
,
Nathan C
. 2000.
Peroxynitrite reductase activity of bacterial peroxiredoxins.
.
Nature. 407(6801):211-5.
2002
Bryk R
,
Lima CD
,
Erdjument-Bromage H
,
Tempst P
,
Nathan C
. 2002.
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
.
Science. 295(5557):1073-7.
Nathan C
. 2002.
Points of control in inflammation.
.
Nature. 420(6917):846-52.
2003
Shi S
,
Nathan C
,
Schnappinger D
,
Drenkow J
,
Fuortes M
,
Block E
,
Ding A
,
Gingeras TR
,
Schoolnik G
,
Akira S
et al.
. 2003.
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
.
J Exp Med. 198(7):987-97.
Schnappinger D
,
Ehrt S
,
Voskuil MI
,
Liu Y
,
Mangan JA
,
Monahan IM
,
Dolganov G
,
Efron B
,
Butcher PD
,
Nathan C
et al.
. 2003.
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.
.
J Exp Med. 198(5):693-704.
2004
Nathan C
. 2004.
Antibiotics at the crossroads.
.
Nature. 431(7011):899-902.
2005
Hisert KB
,
MacCoss M
,
Shiloh MU
,
K Darwin H
,
Singh S
,
Jones RA
,
Ehrt S
,
Zhang Z
,
Gaffney BL
,
Gandotra S
et al.
. 2005.
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
.
Mol Microbiol. 56(5):1234-45.
Nathan C
,
Calingasan N
,
Nezezon J
,
Ding A
,
M Lucia S
,
La Perle K
,
Fuortes M
,
Lin M
,
Ehrt S
,
Kwon NSoo
et al.
. 2005.
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
.
J Exp Med. 202(9):1163-9.
2006
Cohn EF
,
Nathan C
,
Radzioch D
,
Yu H
,
Xiang Z
,
Ding A
. 2006.
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.
.
J Immunol. 176(2):1185-94.
Nathan C
. 2006.
Neutrophils and immunity: challenges and opportunities.
.
Nat Rev Immunol. 6(3):173-82.
2007
Nathan C
. 2007.
Aligning pharmaceutical innovation with medical need.
.
Nat Med. 13(3):304-8.
2008
Gold B
,
Deng H
,
Bryk R
,
Vargas D
,
Eliezer D
,
Roberts J
,
Jiang X
,
Nathan C
. 2008.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
.
Nat Chem Biol. 4(10):609-16.
Bryk R
,
Gold B
,
Venugopal A
,
Singh J
,
Samy R
,
Pupek K
,
Cao H
,
Popescu C
,
Gurney M
,
Hotha S
et al.
. 2008.
Selective killing of nonreplicating mycobacteria.
.
Cell Host Microbe. 3(3):137-45.
2009
Nathan C
. 2009.
Taming tuberculosis: a challenge for science and society.
.
Cell Host Microbe. 5(3):220-4.
2010
de Carvalho LPedro S
,
Zhao H
,
Dickinson CE
,
Arango NM
,
Lima CD
,
Fischer SM
,
Ouerfelli O
,
Nathan C
,
Rhee K
. 2010.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
.
Chem Biol. 17(4):323-32.
Yin F
,
Banerjee R
,
Thomas B
,
Zhou P
,
Qian L
,
Jia T
,
Ma X
,
Ma Y
,
Iadecola C
,
M Beal F
et al.
. 2010.
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
.
J Exp Med. 207(1):117-28.
Seimon TA
,
Kim M-J
,
Blumenthal A
,
Koo J
,
Ehrt S
,
Wainwright H
,
Bekker L-G
,
Kaplan G
,
Nathan C
,
Tabas I
et al.
. 2010.
Induction of ER stress in macrophages of tuberculosis granulomas.
.
PLoS One. 5(9):e12772.
de Carvalho LPedro S
,
Fischer SM
,
Marrero J
,
Nathan C
,
Ehrt S
,
Rhee KY
. 2010.
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
.
Chem Biol. 17(10):1122-31.
Nathan C
,
Ding A
. 2010.
Nonresolving inflammation.
.
Cell. 140(6):871-82.
2011
Rhee KY
,
de Carvalho LPedro Sori
,
Bryk R
,
Ehrt S
,
Marrero J
,
Park SWoong
,
Schnappinger D
,
Venugopal A
,
Nathan C
. 2011.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
.
Trends Microbiol. 19(7):307-14.
de Carvalho LPedro S
,
Darby CM
,
Rhee KY
,
Nathan C
. 2011.
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.
.
ACS Med Chem Lett. 2(11):849-854.
Venugopal A
,
Bryk R
,
Shi S
,
Rhee K
,
Rath P
,
Schnappinger D
,
Ehrt S
,
Nathan C
. 2011.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
.
Cell Host Microbe. 9(1):21-31.
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