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Ehrt, Sabine
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A
Vandal OH
,
Nathan CF
,
Ehrt S
. 2009.
Acid resistance in Mycobacterium tuberculosis.
.
J Bacteriol. 191(15):4714-21.
Vandal OH
,
Roberts JA
,
Odaira T
,
Schnappinger D
,
Nathan CF
,
Ehrt S
. 2009.
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
.
J Bacteriol. 191(2):625-31.
Morris RP
,
Nguyen L
,
Gatfield J
,
Visconti K
,
Nguyen K
,
Schnappinger D
,
Ehrt S
,
Liu Y
,
Heifets L
,
Pieters J
et al.
. 2005.
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 102(34):12200-5.
B
Boshoff HIM
,
Xu X
,
Tahlan K
,
Dowd CS
,
Pethe K
,
Camacho LR
,
Park T-H
,
Yun C-S
,
Schnappinger D
,
Ehrt S
et al.
. 2008.
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
.
J Biol Chem. 283(28):19329-41.
Schnappinger D
,
Ehrt S
. 2016.
A broader spectrum of tuberculosis.
.
Nat Med. 22(10):1076-1077.
C
Rhee KY
,
de Carvalho LPedro Sori
,
Bryk R
,
Ehrt S
,
Marrero J
,
Park SWoong
,
Schnappinger D
,
Venugopal A
,
Nathan C
. 2011.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
.
Trends Microbiol. 19(7):307-14.
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Schnappinger D
,
O'Brien KM
,
Ehrt S
. 2015.
Construction of conditional knockdown mutants in mycobacteria.
.
Methods Mol Biol. 1285:151-75.
Ehrt S
,
Schnappinger D
. 2006.
Controlling gene expression in mycobacteria.
.
Future Microbiol. 1(2):177-84.
Ehrt S
,
Guo XV
,
Hickey CM
,
Ryou M
,
Monteleone M
,
Riley LW
,
Schnappinger D
. 2005.
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.
.
Nucleic Acids Res. 33(2):e21.
Vandal OH
,
Gelb MH
,
Ehrt S
,
Nathan CF
. 2006.
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
.
Infect Immun. 74(3):1751-6.
D
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
Robertson BD
,
Altmann D
,
Barry C
,
Bishai B
,
Cole S
,
Dick T
,
Duncan K
,
Dye C
,
Ehrt S
,
Esmail H
et al.
. 2012.
Detection and treatment of subclinical tuberculosis.
.
Tuberculosis (Edinb). 92(6):447-52.
Shi S
,
Ehrt S
. 2006.
Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
.
Infect Immun. 74(1):56-63.
Goodsmith N
,
Guo XV
,
Vandal OH
,
Vaubourgeix J
,
Wang R
,
Botella H
,
Song S
,
Bhatt K
,
Liba A
,
Salgame P
et al.
. 2015.
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
.
PLoS Pathog. 11(2):e1004645.
Botella H
,
Yang G
,
Ouerfelli O
,
Ehrt S
,
Nathan CF
,
Vaubourgeix J
. 2017.
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
.
mBio. 8(5)
E
Park SWoong
,
Klotzsche M
,
Wilson DJ
,
Boshoff HI
,
Eoh H
,
Manjunatha U
,
Blumenthal A
,
Rhee K
,
Barry CE
,
Aldrich CC
et al.
. 2011.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
.
PLoS Pathog. 7(9):e1002264.
Shi S
,
Blumenthal A
,
Hickey CM
,
Gandotra S
,
Levy D
,
Ehrt S
. 2005.
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
.
J Immunol. 175(5):3318-28.
Schnappinger D
,
Schoolnik GK
,
Ehrt S
. 2006.
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another.
.
Microbes Infect. 8(4):1132-40.
F
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
G
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
Marrero J
,
Rhee KY
,
Schnappinger D
,
Pethe K
,
Ehrt S
. 2010.
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
.
Proc Natl Acad Sci U S A. 107(21):9819-24.
Marrero J
,
Trujillo C
,
Rhee KY
,
Ehrt S
. 2013.
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
.
PLoS Pathog. 9(1):e1003116.
Hisert KB
,
MacCoss M
,
Shiloh MU
,
K Darwin H
,
Singh S
,
Jones RA
,
Ehrt S
,
Zhang Z
,
Gaffney BL
,
Gandotra S
et al.
. 2005.
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
.
Mol Microbiol. 56(5):1234-45.
Santangelo Mde la Paz
,
Gest PM
,
Guerin ME
,
Coinçon M
,
Pham H
,
Ryan G
,
Puckett SE
,
Spencer JS
,
Gonzalez-Juarrero M
,
Daher R
et al.
. 2011.
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
.
J Biol Chem. 286(46):40219-31.
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