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Found 124 results
Author Title [ Type(Desc)] Year
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Journal Article
Blumenthal A, Trujillo C, Ehrt S, Schnappinger D.  2010.  Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.. PLoS One. 5(12):e15667.
Krueger C, Berens C, Schmidt A, Schnappinger D, Hillen W.  2003.  Single-chain Tet transregulators.. Nucleic Acids Res. 31(12):3050-6.
Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn JA, Schnappinger D, Wilkinson RJ, Young D.  2009.  The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.. Nat Rev Microbiol. 7(12):845-55.
Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D et al..  2021.  Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.. ACS Omega. 6(3):2284-2311.
Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D et al..  2022.  Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.. J Med Chem. 65(9):6903-6925.
Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR.  2019.  Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.. BMC Bioinformatics. 20(1):603.
Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O et al..  2015.  Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.. Cell Host Microbe. 17(2):178-90.
Khonde LPeguy, Peton N, Masike K, Valentine T, Zindo F, Fienberg S, Omollo C, Njoroge M, Vallini F, Tammaro C et al..  2026.  Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitors.. Eur J Med Chem. 312:118841.
Liu F, Dawadi S, Maize KM, Dai R, Park SWoong, Schnappinger D, Finzel BC, Aldrich CC.  2017.  Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.. J Med Chem. 60(13):5507-5520.
Krieger IV, Sukheja P, Yang B, Tang S, Selle D, Woods A, Engelhart C, Kumar P, Harbut MB, Liu D et al..  2025.  SuFEx-based antitubercular compound irreversibly inhibits Pks13.. Nature.
Xu Y, Ehrt S, Schnappinger D, Beites T.  2023.  Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation.. mBio. 14(6):e0104523.
Mostert D, Braun J, Zimmerman MD, Engelhart CA, Berndl S, Quoika PK, Kany AM, Proietto J, Penalva-Lopez S, Wallach JB et al..  2025.  Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly.. Chem Sci. 16(21):9472-9483.
Park SWoong, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC et al..  2015.  Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.. Chem Biol. 22(1):76-86.
Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al..  2015.  Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.
Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al..  2018.  Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)
Li W, Obregón-Henao A, Wallach JB, E North J, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M.  2016.  Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.. Antimicrob Agents Chemother. 60(9):5198-207.
Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MAmir, Su H, Trujillo C et al..  2020.  Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.. Antimicrob Agents Chemother. 64(5)
Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C et al..  2003.  Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.. J Exp Med. 198(5):693-704.
Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S.  2014.  Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.
Aldridge BB, Barros-Aguirre D, Barry CE, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu X-J, Cooper CB, Dartois V et al..  2021.  The Tuberculosis Drug Accelerator at year 10: what have we learned? Nat Med. 27(8):1333-1337.
Grover S, Engelhart CA, Pérez-Herrán E, Li W, Abrahams KA, Papavinasasundaram K, Bean JM, Sassetti CM, Mendoza-Losana A, Besra GS et al..  2021.  Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis.. ACS Infect Dis. 7(1):141-152.
Theriault ME, Wong AI, DeJesus MA, Pisu D, Lee BNae Rin, Kirukubar G, Li S, Wallach JB, Schnappinger D, Lê-Bury G et al..  2026.  Utilization of a CRISPRi-based ex vivo challenge model to reveal temporally dependent gene essentiality in intracellular Mycobacterium tuberculosis.. mBio. :e0061026.
Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C.  2011.  Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.. Cell Host Microbe. 9(1):21-31.
Bosch B, DeJesus MA, Schnappinger D, Rock JM.  2024.  Weak links: Advancing target-based drug discovery by identifying the most vulnerable targets.. Ann N Y Acad Sci. 1535(1):10-19.