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The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.

TitleThe spectrum of latent tuberculosis: rethinking the biology and intervention strategies.
Publication TypeJournal Article
Year of Publication2009
AuthorsBarry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn JA, Schnappinger D, Wilkinson RJ, Young D
JournalNat Rev Microbiol
Volume7
Issue12
Pagination845-55
Date Published2009 Dec
ISSN1740-1534
KeywordsAntigens, Bacterial, Antitubercular Agents, Computational Biology, Drug Delivery Systems, Drug Design, Latent Tuberculosis, Mycobacterium tuberculosis, Reagent Kits, Diagnostic, Tuberculosis, Pulmonary
Abstract

Immunological tests provide evidence of latent tuberculosis in one third of the global population, which corresponds to more than two billion individuals. Latent tuberculosis is defined by the absence of clinical symptoms but carries a risk of subsequent progression to clinical disease, particularly in the context of co-infection with HIV. In this Review we discuss the biology of latent tuberculosis as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide microenvironments with differential ability to support or suppress the persistence of viable bacteria. We then show how this model can be used to develop a rational programme to discover effective drugs for the eradication of M. tuberculosis infection.

DOI10.1038/nrmicro2236
Alternate JournalNat Rev Microbiol
PubMed ID19855401
PubMed Central IDPMC4144869
Grant ListR01 HL075845 / HL / NHLBI NIH HHS / United States
88316 / / Wellcome Trust / United Kingdom
MC_U117588499 / / Medical Research Council / United Kingdom
MC_U117581288 / / Medical Research Council / United Kingdom
084323 / / Wellcome Trust / United Kingdom
ZIA AI000783-16 / / Intramural NIH HHS / United States
U117588499(88499) / / Medical Research Council / United Kingdom

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