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Schnappinger, Dirk
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Ballinger E
,
Mosior J
,
Hartman T
,
Burns-Huang K
,
Gold B
,
Morris R
,
Goullieux L
,
Blanc I
,
Vaubourgeix J
,
Lagrange S
et al.
. 2019.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
.
Science. 363(6426)
P
Wang R
,
Kreutzfeldt K
,
Botella H
,
Vaubourgeix J
,
Schnappinger D
,
Ehrt S
. 2019.
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
.
Elife. 8
Beites T
,
O'Brien K
,
Tiwari D
,
Engelhart CA
,
Walters S
,
Andrews J
,
Yang H-J
,
Sutphen ML
,
Weiner DM
,
Dayao EK
et al.
. 2019.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
.
Nat Commun. 10(1):4970.
Raju RM
,
Jedrychowski MP
,
Wei J-R
,
Pinkham JT
,
Park AS
,
O'Brien K
,
Rehren G
,
Schnappinger D
,
Gygi SP
,
Rubin EJ
. 2014.
Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.
.
PLoS Pathog. 10(3):e1003994.
Rock JM
,
Hopkins FF
,
Chavez A
,
Diallo M
,
Chase MR
,
Gerrick ER
,
Pritchard JR
,
Church GM
,
Rubin EJ
,
Sassetti CM
et al.
. 2017.
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.
.
Nat Microbiol. 2:16274.
Kim J-H
,
Wei J-R
,
Wallach JB
,
Robbins RS
,
Rubin EJ
,
Schnappinger D
. 2011.
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase.
.
Nucleic Acids Res. 39(6):2210-20.
R
Chauhan R
,
Ravi J
,
Datta P
,
Chen T
,
Schnappinger D
,
Bassler KE
,
Balázsi G
,
Gennaro MLaura
. 2016.
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.
.
Nat Commun. 7:11062.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1):MGM2-0018-2013.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1)
S
Guo XV
,
Monteleone M
,
Klotzsche M
,
Kamionka A
,
Hillen W
,
Braunstein M
,
Ehrt S
,
Schnappinger D
. 2007.
Silencing Mycobacterium smegmatis by using tetracycline repressors.
.
J Bacteriol. 189(13):4614-23.
Blumenthal A
,
Trujillo C
,
Ehrt S
,
Schnappinger D
. 2010.
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.
.
PLoS One. 5(12):e15667.
Krueger C
,
Berens C
,
Schmidt A
,
Schnappinger D
,
Hillen W
. 2003.
Single-chain Tet transregulators.
.
Nucleic Acids Res. 31(12):3050-6.
Barry CE
,
Boshoff HI
,
Dartois V
,
Dick T
,
Ehrt S
,
Flynn JA
,
Schnappinger D
,
Wilkinson RJ
,
Young D
. 2009.
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.
.
Nat Rev Microbiol. 7(12):845-55.
Subramaniyam S
,
DeJesus MA
,
Zaveri A
,
Smith CM
,
Baker RE
,
Ehrt S
,
Schnappinger D
,
Sassetti CM
,
Ioerger TR
. 2019.
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
.
BMC Bioinformatics. 20(1):603.
Vaubourgeix J
,
Lin G
,
Dhar N
,
Chenouard N
,
Jiang X
,
Botella H
,
Lupoli T
,
Mariani O
,
Yang G
,
Ouerfelli O
et al.
. 2015.
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
.
Cell Host Microbe. 17(2):178-90.
Liu F
,
Dawadi S
,
Maize KM
,
Dai R
,
Park SWoong
,
Schnappinger D
,
Finzel BC
,
Aldrich CC
. 2017.
Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
.
J Med Chem. 60(13):5507-5520.
T
Park SWoong
,
Casalena DE
,
Wilson DJ
,
Dai R
,
Nag PP
,
Liu F
,
Boyce JP
,
Bittker JA
,
Schreiber SL
,
Finzel BC
et al.
. 2015.
Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.
.
Chem Biol. 22(1):76-86.
Bockman MR
,
Kalinda AS
,
Petrelli R
,
De la Mora-Rey T
,
Tiwari D
,
Liu F
,
Dawadi S
,
Nandakumar M
,
Rhee KY
,
Schnappinger D
et al.
. 2015.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
.
J Med Chem. 58(18):7349-7369.
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
Li W
,
Obregón-Henao A
,
Wallach JB
,
E North J
,
Lee RE
,
Gonzalez-Juarrero M
,
Schnappinger D
,
Jackson M
. 2016.
Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.
.
Antimicrob Agents Chemother. 60(9):5198-207.
Gengenbacher M
,
Zimmerman MD
,
Sarathy JP
,
Kaya F
,
Wang H
,
Mina M
,
Carter C
,
Hossen MAmir
,
Su H
,
Trujillo C
et al.
. 2020.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
.
Antimicrob Agents Chemother. 64(5)
Schnappinger D
,
Ehrt S
,
Voskuil MI
,
Liu Y
,
Mangan JA
,
Monahan IM
,
Dolganov G
,
Efron B
,
Butcher PD
,
Nathan C
et al.
. 2003.
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.
.
J Exp Med. 198(5):693-704.
Trujillo C
,
Blumenthal A
,
Marrero J
,
Rhee KY
,
Schnappinger D
,
Ehrt S
. 2014.
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.
.
mBio. 5(2):e00085.
V
Venugopal A
,
Bryk R
,
Shi S
,
Rhee K
,
Rath P
,
Schnappinger D
,
Ehrt S
,
Nathan C
. 2011.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
.
Cell Host Microbe. 9(1):21-31.
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