Microbiology and Immunology

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Gandotra S, Lebron MB, Ehrt S. 2010. The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.. PLoS Pathog. 6(8):e1001040.

Buter J, Cheng T-Y, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN et al.. 2019. Mycobacterium tuberculosis releases an antacid that remodels phagosomes.. Nat Chem Biol. 15(9):889-899.

Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S. 2016. Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.. PLoS Pathog. 12(6):e1005675.

Ehrt S, Schnappinger D. 2007. Mycobacterium tuberculosis virulence: lipids inside and out.. Nat Med. 13(3):284-5.

Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S et al.. 2003. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.. J Exp Med. 198(7):987-97.

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Tan MPing, Sequeira P, Lin WWei, Phong WYee, Cliff P, Ng SHwee, Lee BHeng, Camacho L, Schnappinger D, Ehrt S et al.. 2010. Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses.. PLoS One. 5(10):e13356.

Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S. 2007. Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis.. Infect Immun. 75(11):5127-34.

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Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS et al.. 2014. An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.. Proc Natl Acad Sci U S A. 111(18):6750-5.

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Healy C, Gouzy A, Ehrt S. 2020. Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.. mBio. 11(2)

Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. 2019. Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.. Elife. 8

Small JL, Park SWoong, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. 2013. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.. mBio. 4(5):e00475-13.

Koo M-S, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S et al.. 2011. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.. PLoS One. 6(2):e17091.

Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang H-J, Sutphen ML, Weiner DM, Dayao EK et al.. 2019. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.. Nat Commun. 10(1):4970.

K Darwin H, Ehrt S, Gutierrez-Ramos J-C, Weich N, Nathan CF. 2003. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.. Science. 302(5652):1963-6.

Nathan C, Calingasan N, Nezezon J, Ding A, M Lucia S, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NSoo et al.. 2005. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.. J Exp Med. 202(9):1163-9.

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Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1):MGM2-0018-2013.

Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1)

Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S. 2009. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.. Cell Host Microbe. 5(1):35-46.

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Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S et al.. 2008. Selective killing of nonreplicating mycobacteria.. Cell Host Microbe. 3(3):137-45.

Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D. 2007. Silencing Mycobacterium smegmatis by using tetracycline repressors.. J Bacteriol. 189(13):4614-23.

Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. 2010. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.. PLoS One. 5(12):e15667.

Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn JA, Schnappinger D, Wilkinson RJ, Young D. 2009. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.. Nat Rev Microbiol. 7(12):845-55.

Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR. 2019. Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.. BMC Bioinformatics. 20(1):603.

Biswas T, Small J, Vandal O, Odaira T, Deng H, Ehrt S, Tsodikov OV. 2010. Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.. Structure. 18(10):1353-63.

Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. 2013. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.. J Biol Chem. 288(18):12489-99.