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Found 85 results
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Ehrt, Sabine
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2015
Ganapathy U
,
Marrero J
,
Calhoun S
,
Eoh H
,
de Carvalho LPedro Sori
,
Rhee K
,
Ehrt S
. 2015.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
.
Nat Commun. 6:7912.
2014
Puckett S
,
Trujillo C
,
Eoh H
,
Marrero J
,
Spencer J
,
Jackson M
,
Schnappinger D
,
Rhee K
,
Ehrt S
. 2014.
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
.
PLoS Pathog. 10(5):e1004144.
Gaur RL
,
Ren K
,
Blumenthal A
,
Bhamidi S
,
González-Nilo FD
,
Gibbs S
,
Jackson M
,
Zare RN
,
Ehrt S
,
Ernst JD
et al.
. 2014.
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
.
PLoS Pathog. 10(9):e1004376.
Danilchanka O
,
Sun J
,
Pavlenok M
,
Maueröder C
,
Speer A
,
Siroy A
,
Marrero J
,
Trujillo C
,
Mayhew DL
,
Doornbos KS
et al.
. 2014.
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.
.
Proc Natl Acad Sci U S A. 111(18):6750-5.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1):MGM2-0018-2013.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1)
Trujillo C
,
Blumenthal A
,
Marrero J
,
Rhee KY
,
Schnappinger D
,
Ehrt S
. 2014.
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.
.
mBio. 5(2):e00085.
2013
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
Marrero J
,
Trujillo C
,
Rhee KY
,
Ehrt S
. 2013.
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
.
PLoS Pathog. 9(1):e1003116.
Sakamoto K
,
Kim MJeong
,
Rhoades ER
,
Allavena RE
,
Ehrt S
,
Wainwright HC
,
Russell DG
,
Rohde KH
. 2013.
Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.
.
Infect Immun. 81(3):764-76.
Ehrt S
,
Rhee K
. 2013.
Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.
.
Curr Top Microbiol Immunol. 374:163-88.
Small JL
,
Park SWoong
,
Kana BD
,
Ioerger TR
,
Sacchettini JC
,
Ehrt S
. 2013.
Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.
.
mBio. 4(5):e00475-13.
Small JL
,
O'Donoghue AJ
,
Boritsch EC
,
Tsodikov OV
,
Knudsen GM
,
Vandal O
,
Craik CS
,
Ehrt S
. 2013.
Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.
.
J Biol Chem. 288(18):12489-99.
Darby CM
,
Ingólfsson HI
,
Jiang X
,
Shen C
,
Sun M
,
Zhao N
,
Burns K
,
Liu G
,
Ehrt S
,
J Warren D
et al.
. 2013.
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.
.
PLoS One. 8(7):e68942.
2012
Robertson BD
,
Altmann D
,
Barry C
,
Bishai B
,
Cole S
,
Dick T
,
Duncan K
,
Dye C
,
Ehrt S
,
Esmail H
et al.
. 2012.
Detection and treatment of subclinical tuberculosis.
.
Tuberculosis (Edinb). 92(6):447-52.
Blumenthal A
,
Nagalingam G
,
Huch JH
,
Walker L
,
Guillemin GJ
,
Smythe GA
,
Ehrt S
,
Britton WJ
,
Saunders BM
. 2012.
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
.
PLoS One. 7(5):e37314.
2011
Rhee KY
,
de Carvalho LPedro Sori
,
Bryk R
,
Ehrt S
,
Marrero J
,
Park SWoong
,
Schnappinger D
,
Venugopal A
,
Nathan C
. 2011.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
.
Trends Microbiol. 19(7):307-14.
Park SWoong
,
Klotzsche M
,
Wilson DJ
,
Boshoff HI
,
Eoh H
,
Manjunatha U
,
Blumenthal A
,
Rhee K
,
Barry CE
,
Aldrich CC
et al.
. 2011.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
.
PLoS Pathog. 7(9):e1002264.
Santangelo Mde la Paz
,
Gest PM
,
Guerin ME
,
Coinçon M
,
Pham H
,
Ryan G
,
Puckett SE
,
Spencer JS
,
Gonzalez-Juarrero M
,
Daher R
et al.
. 2011.
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
.
J Biol Chem. 286(46):40219-31.
Darby CM
,
Venugopal A
,
Ehrt S
,
Nathan CF
. 2011.
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.
.
Tuberculosis (Edinb). 91(5):343-7.
Koo M-S
,
Manca C
,
Yang G
,
O'Brien P
,
Sung N
,
Tsenova L
,
Subbian S
,
Fallows D
,
Muller G
,
Ehrt S
et al.
. 2011.
Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.
.
PLoS One. 6(2):e17091.
Venugopal A
,
Bryk R
,
Shi S
,
Rhee K
,
Rath P
,
Schnappinger D
,
Ehrt S
,
Nathan C
. 2011.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
.
Cell Host Microbe. 9(1):21-31.
2010
Marrero J
,
Rhee KY
,
Schnappinger D
,
Pethe K
,
Ehrt S
. 2010.
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
.
Proc Natl Acad Sci U S A. 107(21):9819-24.
Seimon TA
,
Kim M-J
,
Blumenthal A
,
Koo J
,
Ehrt S
,
Wainwright H
,
Bekker L-G
,
Kaplan G
,
Nathan C
,
Tabas I
et al.
. 2010.
Induction of ER stress in macrophages of tuberculosis granulomas.
.
PLoS One. 5(9):e12772.
de Carvalho LPedro S
,
Fischer SM
,
Marrero J
,
Nathan C
,
Ehrt S
,
Rhee KY
. 2010.
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
.
Chem Biol. 17(10):1122-31.
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