Microbiology and Immunology

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Found 85 results
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Journal Article
Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S.  2019.  Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.. Elife. 8
Healy C, Gouzy A, Ehrt S.  2020.  Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.. mBio. 11(2)
Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS et al..  2014.  An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.. Proc Natl Acad Sci U S A. 111(18):6750-5.
Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S.  2007.  Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis.. Infect Immun. 75(11):5127-34.
Tan MPing, Sequeira P, Lin WWei, Phong WYee, Cliff P, Ng SHwee, Lee BHeng, Camacho L, Schnappinger D, Ehrt S et al..  2010.  Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses.. PLoS One. 5(10):e13356.
Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S et al..  2003.  MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.. J Exp Med. 198(7):987-97.
Ehrt S, Schnappinger D.  2007.  Mycobacterium tuberculosis virulence: lipids inside and out.. Nat Med. 13(3):284-5.
Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S.  2016.  Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.. PLoS Pathog. 12(6):e1005675.
Buter J, Cheng T-Y, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN et al..  2019.  Mycobacterium tuberculosis releases an antacid that remodels phagosomes.. Nat Chem Biol. 15(9):889-899.
Gandotra S, Lebron MB, Ehrt S.  2010.  The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.. PLoS Pathog. 6(8):e1001040.
Botella H, Vaubourgeix J, Lee MHee, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S.  2017.  Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.. EMBO J. 36(4):536-548.
Ehrt S, Rhee K.  2013.  Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.
Darby CM, Venugopal A, Ehrt S, Nathan CF.  2011.  Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.. Tuberculosis (Edinb). 91(5):343-7.
Sakamoto K, Kim MJeong, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH.  2013.  Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.. Infect Immun. 81(3):764-76.
Ehrt S, Schnappinger D.  2009.  Mycobacterial survival strategies in the phagosome: defence against host stresses.. Cell Microbiol. 11(8):1170-8.
Stephanou NC, Gao F, Bongiorno P, Ehrt S, Schnappinger D, Shuman S, Glickman MS.  2007.  Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks.. J Bacteriol. 189(14):5237-46.
Ehrt S, Rhee K, Schnappinger D.  2015.  Mycobacterial genes essential for the pathogen's survival in the host.. Immunol Rev. 264(1):319-26.
de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY.  2010.  Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.
Ehrt S, Schnappinger D, Rhee KY.  2018.  Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.
Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S.  2008.  A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.. Nat Med. 14(8):849-54.
Blumenthal A, Nagalingam G, Huch JH, Walker L, Guillemin GJ, Smythe GA, Ehrt S, Britton WJ, Saunders BM.  2012.  M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.. PLoS One. 7(5):e37314.
Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD et al..  2014.  LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.. PLoS Pathog. 10(9):e1004376.
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N et al..  2019.  Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. Nature. 571(7763):72-78.
Ehrt S, Schnappinger D.  2003.  Isolation of plasmids from E. coli by boiling lysis.. Methods Mol Biol. 235:79-82.
Ehrt S, Schnappinger D.  2003.  Isolation of plasmids from E. coli by alkaline lysis.. Methods Mol Biol. 235:75-8.