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Mycobacterial survival strategies in the phagosome: defence against host stresses.

TitleMycobacterial survival strategies in the phagosome: defence against host stresses.
Publication TypeJournal Article
Year of Publication2009
AuthorsEhrt S, Schnappinger D
JournalCell Microbiol
Volume11
Issue8
Pagination1170-8
Date Published2009 Aug
ISSN1462-5822
KeywordsBacterial Capsules, Host-Pathogen Interactions, Humans, Hydrogen-Ion Concentration, Mycobacterium tuberculosis, Oxidative Stress, Phagosomes, Reactive Nitrogen Species, Tuberculosis, Virulence
Abstract

Infections with Mycobacterium tuberculosis remain a major cause of disease and death in humans. Among the factors that contribute to M. tuberculosis's success as a pathogen is its ability to withstand potentially bactericidal host defences and to resist elimination by an activated immune system. This resistance to killing by the host is in part due to the low permeability of the mycobacterial cell envelope for many toxic molecules. In addition, it depends upon the detoxification of reactive oxygen and reactive nitrogen molecules produced by the host, the repair of the damage these molecules cause and maintenance of a neutral intrabacterial pH within acidic environments. The latter three mechanisms are the focus of this review.

DOI10.1111/j.1462-5822.2009.01335.x
Alternate JournalCell Microbiol
PubMed ID19438516
PubMed Central IDPMC3170014
Grant ListR01 AI081725 / AI / NIAID NIH HHS / United States
R01 AI063446 / AI / NIAID NIH HHS / United States
AI063446 / AI / NIAID NIH HHS / United States
R01 AI081725-01 / AI / NIAID NIH HHS / United States
AI081725 / AI / NIAID NIH HHS / United States
R01 AI057443 / AI / NIAID NIH HHS / United States
R01 AI057443-04 / AI / NIAID NIH HHS / United States
AI057443 / AI / NIAID NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R01 AI063446-04 / AI / NIAID NIH HHS / United States

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