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Schnappinger D
,
Ehrt S
. 2006.
Introduction: genomic approaches in infectious diseases.
.
Microbes Infect. 8(6):1611-2.
Ding A
,
Yu H
,
Yang J
,
Shi S
,
Ehrt S
. 2005.
Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88.
.
Immunology. 116(3):381-9.
Seimon TA
,
Kim M-J
,
Blumenthal A
,
Koo J
,
Ehrt S
,
Wainwright H
,
Bekker L-G
,
Kaplan G
,
Nathan C
,
Tabas I
et al.
. 2010.
Induction of ER stress in macrophages of tuberculosis granulomas.
.
PLoS One. 5(9):e12772.
Puckett S
,
Trujillo C
,
Eoh H
,
Marrero J
,
Spencer J
,
Jackson M
,
Schnappinger D
,
Rhee K
,
Ehrt S
. 2014.
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
.
PLoS Pathog. 10(5):e1004144.
Gandotra S
,
Schnappinger D
,
Monteleone M
,
Hillen W
,
Ehrt S
. 2007.
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.
.
Nat Med. 13(12):1515-20.
Klotzsche M
,
Ehrt S
,
Schnappinger D
. 2009.
Improved tetracycline repressors for gene silencing in mycobacteria.
.
Nucleic Acids Res. 37(6):1778-88.
Zhao N
,
Sun M
,
Burns-Huang K
,
Jiang X
,
Ling Y
,
Darby C
,
Ehrt S
,
Liu G
,
Nathan C
. 2015.
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
.
PLoS One. 10(5):e0126211.
Wescott HH
,
Zuniga ES
,
Bajpai A
,
Trujillo C
,
Ehrt S
,
Schnappinger D
,
Roberts DM
,
Parish T
. 2018.
Identification of Enolase as the Target of 2-Aminothiazoles in .
.
Front Microbiol. 9:2542.
H
Shimono N
,
Morici L
,
Casali N
,
Cantrell S
,
Sidders B
,
Ehrt S
,
Riley LW
. 2003.
Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon.
.
Proc Natl Acad Sci U S A. 100(26):15918-23.
G
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Santangelo Mde la Paz
,
Gest PM
,
Guerin ME
,
Coinçon M
,
Pham H
,
Ryan G
,
Puckett SE
,
Spencer JS
,
Gonzalez-Juarrero M
,
Daher R
et al.
. 2011.
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
.
J Biol Chem. 286(46):40219-31.
Hisert KB
,
MacCoss M
,
Shiloh MU
,
K Darwin H
,
Singh S
,
Jones RA
,
Ehrt S
,
Zhang Z
,
Gaffney BL
,
Gandotra S
et al.
. 2005.
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
.
Mol Microbiol. 56(5):1234-45.
Marrero J
,
Trujillo C
,
Rhee KY
,
Ehrt S
. 2013.
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
.
PLoS Pathog. 9(1):e1003116.
Marrero J
,
Rhee KY
,
Schnappinger D
,
Pethe K
,
Ehrt S
. 2010.
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
.
Proc Natl Acad Sci U S A. 107(21):9819-24.
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
F
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
E
Schnappinger D
,
Schoolnik GK
,
Ehrt S
. 2006.
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another.
.
Microbes Infect. 8(4):1132-40.
Shi S
,
Blumenthal A
,
Hickey CM
,
Gandotra S
,
Levy D
,
Ehrt S
. 2005.
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
.
J Immunol. 175(5):3318-28.
Park SWoong
,
Klotzsche M
,
Wilson DJ
,
Boshoff HI
,
Eoh H
,
Manjunatha U
,
Blumenthal A
,
Rhee K
,
Barry CE
,
Aldrich CC
et al.
. 2011.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
.
PLoS Pathog. 7(9):e1002264.
D
Botella H
,
Yang G
,
Ouerfelli O
,
Ehrt S
,
Nathan CF
,
Vaubourgeix J
. 2017.
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
.
mBio. 8(5)
Goodsmith N
,
Guo XV
,
Vandal OH
,
Vaubourgeix J
,
Wang R
,
Botella H
,
Song S
,
Bhatt K
,
Liba A
,
Salgame P
et al.
. 2015.
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
.
PLoS Pathog. 11(2):e1004645.
Shi S
,
Ehrt S
. 2006.
Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
.
Infect Immun. 74(1):56-63.
Robertson BD
,
Altmann D
,
Barry C
,
Bishai B
,
Cole S
,
Dick T
,
Duncan K
,
Dye C
,
Ehrt S
,
Esmail H
et al.
. 2012.
Detection and treatment of subclinical tuberculosis.
.
Tuberculosis (Edinb). 92(6):447-52.
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
C
Vandal OH
,
Gelb MH
,
Ehrt S
,
Nathan CF
. 2006.
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
.
Infect Immun. 74(3):1751-6.
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