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Early J
,
Ollinger J
,
Darby C
,
Alling T
,
Mullen S
,
Casey A
,
Gold B
,
Ochoada J
,
Wiernicki T
,
Masquelin T
et al.
. 2019.
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
.
ACS Infect Dis. 5(2):272-280.
Negri A
,
Javidnia P
,
Mu R
,
Zhang X
,
Vendome J
,
Gold B
,
Roberts J
,
Barman D
,
Ioerger T
,
Sacchettini JC
et al.
. 2018.
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
.
ACS Infect Dis. 4(5):771-787.
Gold B
,
Deng H
,
Bryk R
,
Vargas D
,
Eliezer D
,
Roberts J
,
Jiang X
,
Nathan C
. 2008.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
.
Nat Chem Biol. 4(10):609-16.
F
Nathan C
. 2012.
Fresh approaches to anti-infective therapies.
.
Sci Transl Med. 4(140):140sr2.
E
Mundhra S
,
Bryk R
,
Hawryluk N
,
Zhang T
,
Jiang X
,
Nathan C
. 2018.
Evidence for dispensability of protein kinase R in host control of tuberculosis.
.
Eur J Immunol. 48(4):612-620.
Zimmerman M
,
McDonald SL
,
Ho-Liang H-P
,
Porubsky P
,
Nguyen Q
,
Pharr CW
,
Perkowski AJ
,
Smith R
,
Schoenen FJ
,
Gold BS
et al.
. 2019.
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.
.
J Antibiot (Tokyo). 72(6):469-475.
Maksymiuk C
,
Balakrishnan A
,
Bryk R
,
Rhee KY
,
Nathan C
. 2015.
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
.
Proc Natl Acad Sci U S A. 112(43):E5834-43.
D
Quezada LLopez
,
Li K
,
McDonald SL
,
Nguyen Q
,
Perkowski AJ
,
Pharr CW
,
Gold B
,
Roberts J
,
McAulay K
,
Saito K
et al.
. 2019.
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating .
.
ACS Infect Dis. 5(8):1433-1445.
McAulay K
,
Saito K
,
Warrier T
,
Walsh KFrances
,
Mathurin LDaniel
,
Royal-Mardi G
,
Lee MHee
,
Ocheretina O
,
Pape JWilliam
,
Fitzgerald DW
et al.
. 2018.
Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment.
.
mBio. 9(6)
Wu J
,
Mu R
,
Sun M
,
Zhao N
,
Pan M
,
Li H
,
Dong Y
,
Sun Z
,
Bai J
,
Hu M
et al.
. 2019.
Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in .
.
ACS Infect Dis. 5(7):1087-1104.
C
Nathan C
. 2015.
Cooperative development of antimicrobials: looking back to look ahead.
.
Nat Rev Microbiol. 13(10):651-7.
Xie QW
,
Cho HJ
,
Calaycay J
,
Mumford RA
,
Swiderek KM
,
Lee TD
,
Ding A
,
Troso T
,
Nathan C
. 1992.
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
.
Science. 256(5054):225-8.
B
Karreci ESula
,
Fan H
,
Uehara M
,
Mihali AB
,
Singh PK
,
Kurdi AT
,
Solhjou Z
,
Riella LV
,
Ghobrial I
,
Laragione T
et al.
. 2016.
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
.
Proc Natl Acad Sci U S A. 113(52):E8425-E8432.
Quezada LLopez
,
Silve S
,
Kelinske M
,
Liba A
,
Gonzalez CDiaz
,
Kotev M
,
Goullieux L
,
Sans S
,
Roubert C
,
Lagrange S
et al.
. 2019.
Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.
.
mBio. 10(4)
A
Nathan C
. 2004.
Antibiotics at the crossroads.
.
Nature. 431(7011):899-902.
Nathan C
,
Cars O
. 2014.
Antibiotic resistance--problems, progress, and prospects.
.
N Engl J Med. 371(19):1761-3.
MacMicking JD
,
Nathan C
,
Hom G
,
Chartrain N
,
Fletcher DS
,
Trumbauer M
,
Stevens K
,
Xie QW
,
Sokol K
,
Hutchinson N
. 1995.
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.
.
Cell. 81(4):641-50.
Nathan C
. 2007.
Aligning pharmaceutical innovation with medical need.
.
Nat Med. 13(3):304-8.
de Carvalho LPedro S
,
Zhao H
,
Dickinson CE
,
Arango NM
,
Lima CD
,
Fischer SM
,
Ouerfelli O
,
Nathan C
,
Rhee K
. 2010.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
.
Chem Biol. 17(4):323-32.
Cohn EF
,
Nathan C
,
Radzioch D
,
Yu H
,
Xiang Z
,
Ding A
. 2006.
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.
.
J Immunol. 176(2):1185-94.
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