Microbiology and Immunology

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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

TitleEffect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.
Publication TypeJournal Article
Year of Publication2019
AuthorsZimmerman M, McDonald SL, Ho-Liang H-P, Porubsky P, Nguyen Q, Pharr CW, Perkowski AJ, Smith R, Schoenen FJ, Gold BS, Zhang D, Nathan C, Dartois V, Aubé J
JournalJ Antibiot (Tokyo)
Volume72
Issue6
Pagination469-475
Date Published2019 06
ISSN1881-1469
KeywordsAnimals, Anti-Bacterial Agents, Cephalosporins, Mice, Molecular Structure, Structure-Activity Relationship
Abstract

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

DOI10.1038/s41429-019-0167-y
Alternate JournalJ. Antibiot.
PubMed ID30903100
Grant ListS10 OD023524 / OD / NIH HHS / United States
U54 HG005031 / HG / NHGRI NIH HHS / United States
U19 AI111143 / AI / NIAID NIH HHS / United States

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