Submitted by oks4001 on January 24, 2020 - 1:11pm
| Title | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Zimmerman M, McDonald SL, Ho-Liang H-P, Porubsky P, Nguyen Q, Pharr CW, Perkowski AJ, Smith R, Schoenen FJ, Gold BS, Zhang D, Nathan C, Dartois V, Aubé J |
| Journal | J Antibiot (Tokyo) |
| Volume | 72 |
| Issue | 6 |
| Pagination | 469-475 |
| Date Published | 2019 06 |
| ISSN | 1881-1469 |
| Keywords | Animals, Anti-Bacterial Agents, Cephalosporins, Mice, Molecular Structure, Structure-Activity Relationship |
| Abstract | A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma. |
| DOI | 10.1038/s41429-019-0167-y |
| Alternate Journal | J. Antibiot. |
| PubMed ID | 30903100 |
| Grant List | S10 OD023524 / OD / NIH HHS / United States U54 HG005031 / HG / NHGRI NIH HHS / United States U19 AI111143 / AI / NIAID NIH HHS / United States |