Microbiology and Immunology

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Found 74 results

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2015

Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O et al.. 2015. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.. Cell Host Microbe. 17(2):178-90.

Park SWoong, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC et al.. 2015. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.. Chem Biol. 22(1):76-86.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al.. 2015. Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.

2016

Schnappinger D, Ehrt S. 2016. A broader spectrum of tuberculosis.. Nat Med. 22(10):1076-1077.

Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S. 2016. Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.. PLoS Pathog. 12(6):e1005675.

Chauhan R, Ravi J, Datta P, Chen T, Schnappinger D, Bassler KE, Balázsi G, Gennaro MLaura. 2016. Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.. Nat Commun. 7:11062.

Li W, Obregón-Henao A, Wallach JB, E North J, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M. 2016. Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.. Antimicrob Agents Chemother. 60(9):5198-207.

2017

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SWoong, Ioerger TR et al.. 2017. Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 61(12)

Botella L, Vaubourgeix J, Livny J, Schnappinger D. 2017. Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.. Nat Commun. 8:14731.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. 2017. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM et al.. 2017. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.. Nat Microbiol. 2:16274.

Liu F, Dawadi S, Maize KM, Dai R, Park SWoong, Schnappinger D, Finzel BC, Aldrich CC. 2017. Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.. J Med Chem. 60(13):5507-5520.

2018

Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N et al.. 2018. Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.. J Med Chem. 61(22):9952-9965.

Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T. 2018. Identification of Enolase as the Target of 2-Aminothiazoles in .. Front Microbiol. 9:2542.

Ehrt S, Schnappinger D, Rhee KY. 2018. Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

2019

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N et al.. 2019. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. Nature. 571(7763):72-78.

Freire DMendes, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V et al.. 2019. An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.. Mol Cell. 73(6):1282-1291.e8.

Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S et al.. 2019. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.. Science. 363(6426)

Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. 2019. Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.. Elife. 8

Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang H-J, Sutphen ML, Weiner DM, Dayao EK et al.. 2019. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.. Nat Commun. 10(1):4970.

Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR. 2019. Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.. BMC Bioinformatics. 20(1):603.

2020

Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt S et al.. 2020. Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.. Mol Microbiol.

Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MAmir, Su H, Trujillo C et al.. 2020. Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.. Antimicrob Agents Chemother. 64(5)