Microbiology and Immunology

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Found 76 results
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2012
Wu K, Koo J, Jiang X, Chen R, Cohen SN, Nathan C.  2012.  Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.. PLoS One. 7(2):e30512.
2011
Rhee KY, de Carvalho LPedro Sori, Bryk R, Ehrt S, Marrero J, Park SWoong, Schnappinger D, Venugopal A, Nathan C.  2011.  Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.. Trends Microbiol. 19(7):307-14.
de Carvalho LPedro S, Darby CM, Rhee KY, Nathan C.  2011.  Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.. ACS Med Chem Lett. 2(11):849-854.
Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C.  2011.  Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.. Cell Host Microbe. 9(1):21-31.
2010
de Carvalho LPedro S, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee K.  2010.  Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.. Chem Biol. 17(4):323-32.
Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, M Beal F et al..  2010.  Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.. J Exp Med. 207(1):117-28.
Seimon TA, Kim M-J, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker L-G, Kaplan G, Nathan C, Tabas I et al..  2010.  Induction of ER stress in macrophages of tuberculosis granulomas.. PLoS One. 5(9):e12772.
de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY.  2010.  Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.
Nathan C, Ding A.  2010.  Nonresolving inflammation.. Cell. 140(6):871-82.
2009
Nathan C.  2009.  Taming tuberculosis: a challenge for science and society.. Cell Host Microbe. 5(3):220-4.
2008
Gold B, Deng H, Bryk R, Vargas D, Eliezer D, Roberts J, Jiang X, Nathan C.  2008.  Identification of a copper-binding metallothionein in pathogenic mycobacteria.. Nat Chem Biol. 4(10):609-16.
Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S et al..  2008.  Selective killing of nonreplicating mycobacteria.. Cell Host Microbe. 3(3):137-45.
2007
Nathan C.  2007.  Aligning pharmaceutical innovation with medical need.. Nat Med. 13(3):304-8.
2006
Cohn EF, Nathan C, Radzioch D, Yu H, Xiang Z, Ding A.  2006.  Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.. J Immunol. 176(2):1185-94.
Nathan C.  2006.  Neutrophils and immunity: challenges and opportunities.. Nat Rev Immunol. 6(3):173-82.
2005
Hisert KB, MacCoss M, Shiloh MU, K Darwin H, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S et al..  2005.  A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.. Mol Microbiol. 56(5):1234-45.
Nathan C, Calingasan N, Nezezon J, Ding A, M Lucia S, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NSoo et al..  2005.  Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.. J Exp Med. 202(9):1163-9.
2004
Nathan C.  2004.  Antibiotics at the crossroads.. Nature. 431(7011):899-902.
2003
Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S et al..  2003.  MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.. J Exp Med. 198(7):987-97.
Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C et al..  2003.  Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.. J Exp Med. 198(5):693-704.
2002
Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C.  2002.  Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.. Science. 295(5557):1073-7.
Nathan C.  2002.  Points of control in inflammation.. Nature. 420(6917):846-52.
2000
Bryk R, Griffin P, Nathan C.  2000.  Peroxynitrite reductase activity of bacterial peroxiredoxins.. Nature. 407(6801):211-5.
1997
MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan C.  1997.  Identification of nitric oxide synthase as a protective locus against tuberculosis.. Proc Natl Acad Sci U S A. 94(10):5243-8.
1995
MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N.  1995.  Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.. Cell. 81(4):641-50.