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Microbiology and Immunology

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Journal Article
Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S.  2017.  Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Shimono N, Morici L, Casali N, Cantrell S, Sidders B, Ehrt S, Riley LW.  2003.  Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon.. Proc Natl Acad Sci U S A. 100(26):15918-23.
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T.  2018.  Identification of Enolase as the Target of 2-Aminothiazoles in .. Front Microbiol. 9:2542.
Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C.  2015.  Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.. PLoS One. 10(5):e0126211.
Klotzsche M, Ehrt S, Schnappinger D.  2009.  Improved tetracycline repressors for gene silencing in mycobacteria.. Nucleic Acids Res. 37(6):1778-88.
Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S.  2007.  In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.. Nat Med. 13(12):1515-20.
Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S.  2014.  Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.
Seimon TA, Kim M-J, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker L-G, Kaplan G, Nathan C, Tabas I et al..  2010.  Induction of ER stress in macrophages of tuberculosis granulomas.. PLoS One. 5(9):e12772.
Ding A, Yu H, Yang J, Shi S, Ehrt S.  2005.  Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88.. Immunology. 116(3):381-9.
Schnappinger D, Ehrt S.  2006.  Introduction: genomic approaches in infectious diseases.. Microbes Infect. 8(6):1611-2.
Ehrt S, Schnappinger D.  2003.  Isolation of plasmids from E. coli by alkaline lysis.. Methods Mol Biol. 235:75-8.
Ehrt S, Schnappinger D.  2003.  Isolation of plasmids from E. coli by boiling lysis.. Methods Mol Biol. 235:79-82.
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N et al..  2019.  Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. Nature. 571(7763):72-78.
Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD et al..  2014.  LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.. PLoS Pathog. 10(9):e1004376.
Blumenthal A, Nagalingam G, Huch JH, Walker L, Guillemin GJ, Smythe GA, Ehrt S, Britton WJ, Saunders BM.  2012.  M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.. PLoS One. 7(5):e37314.
Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S.  2008.  A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.. Nat Med. 14(8):849-54.
Ehrt S, Schnappinger D, Rhee KY.  2018.  Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.
de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY.  2010.  Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.
Ehrt S, Rhee K, Schnappinger D.  2015.  Mycobacterial genes essential for the pathogen's survival in the host.. Immunol Rev. 264(1):319-26.
Stephanou NC, Gao F, Bongiorno P, Ehrt S, Schnappinger D, Shuman S, Glickman MS.  2007.  Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks.. J Bacteriol. 189(14):5237-46.
Ehrt S, Schnappinger D.  2009.  Mycobacterial survival strategies in the phagosome: defence against host stresses.. Cell Microbiol. 11(8):1170-8.
Sakamoto K, Kim MJeong, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH.  2013.  Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.. Infect Immun. 81(3):764-76.
Darby CM, Venugopal A, Ehrt S, Nathan CF.  2011.  Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.. Tuberculosis (Edinb). 91(5):343-7.
Ehrt S, Rhee K.  2013.  Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.
Botella H, Vaubourgeix J, Lee MHee, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S.  2017.  Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.. EMBO J. 36(4):536-548.