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Moore, John P
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Berro R
,
Sanders RW
,
Lu M
,
Klasse PJ
,
Moore JP
. 2009.
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
.
PLoS Pathog. 5(8):e1000548.
Veazey RS
,
Ketas TA
,
Klasse PJohan
,
Davison DK
,
Singletary M
,
Green LC
,
Greenberg ML
,
Moore JP
. 2008.
Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.
.
Proc Natl Acad Sci U S A. 105(30):10531-6.
Harris A
,
Borgnia MJ
,
Shi D
,
Bartesaghi A
,
He H
,
Pejchal R
,
Kang YKenneth
,
Depetris R
,
Marozsan AJ
,
Sanders RW
et al.
. 2011.
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
.
Proc Natl Acad Sci U S A. 108(28):11440-5.
Melchers M
,
Bontjer I
,
Tong T
,
P Y Chung N
,
Klasse PJohan
,
Eggink D
,
Montefiori DC
,
Gentile M
,
Cerutti A
,
Olson WC
et al.
. 2012.
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
.
J Virol. 86(5):2488-500.
S
R Malcolm K
,
Veazey RS
,
Geer L
,
Lowry D
,
Fetherston SM
,
Murphy DJ
,
Boyd P
,
Major I
,
Shattock RJ
,
Klasse PJohan
et al.
. 2012.
Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques.
.
Antimicrob Agents Chemother. 56(5):2251-8.
Liu J
,
Deng Y
,
Dey AK
,
Moore JP
,
Lu M
. 2009.
Structure of the HIV-1 gp41 membrane-proximal ectodomain region in a putative prefusion conformation.
.
Biochemistry. 48(13):2915-23.
Kang YKenneth
,
Andjelic S
,
Binley JM
,
Crooks ET
,
Franti M
,
Iyer SPrasad N
,
Donovan GP
,
Dey AK
,
Zhu P
,
Roux KH
et al.
. 2009.
Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1.
.
Vaccine. 27(37):5120-32.
W Horne S
,
Johnson LM
,
Ketas TJ
,
Klasse PJohan
,
Lu M
,
Moore JP
,
Gellman SH
. 2009.
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.
.
Proc Natl Acad Sci U S A. 106(35):14751-6.
Bontjer I
,
Melchers M
,
Eggink D
,
David K
,
Moore JP
,
Berkhout B
,
Sanders RW
. 2010.
Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.
.
J Biol Chem. 285(47):36456-70.
Melchers M
,
Matthews K
,
de Vries RP
,
Eggink D
,
van Montfort T
,
Bontjer I
,
van de Sandt C
,
David K
,
Berkhout B
,
Moore JP
et al.
. 2011.
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells.
.
Retrovirology. 8:48.
Dey AK
,
David KB
,
Klasse PJ
,
Moore JP
. 2007.
Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1.
.
Virology. 360(1):199-208.
Tsibris AMN
,
Pal U
,
Schure AL
,
Veazey RS
,
Kunstman KJ
,
Henrich TJ
,
Klasse PJ
,
Wolinsky SM
,
Kuritzkes DR
,
Moore JP
. 2011.
SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.
.
PLoS One. 6(12):e28047.
R
Liu J
,
Deng Y
,
Li Q
,
Dey AK
,
Moore JP
,
Lu M
. 2010.
Role of a putative gp41 dimerization domain in human immunodeficiency virus type 1 membrane fusion.
.
J Virol. 84(1):201-9.
Anastassopoulou CG
,
Ketas TJ
,
Klasse PJohan
,
Moore JP
. 2009.
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.
.
Proc Natl Acad Sci U S A. 106(13):5318-23.
Anastassopoulou CG
,
Ketas TJ
,
Depetris RS
,
Thomas AM
,
Klasse PJohan
,
Moore JP
. 2011.
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.
.
Virology. 413(1):47-59.
P
Veazey RS
,
Ketas TJ
,
Dufour J
,
Moroney-Rasmussen T
,
Green LC
,
Klasse PJ
,
Moore JP
. 2010.
Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor.
.
J Infect Dis. 202(5):739-44.
Veazey RS
,
Klasse PJohan
,
Schader SM
,
Hu Q
,
Ketas TJ
,
Lu M
,
Marx PA
,
Dufour J
,
Colonno RJ
,
Shattock RJ
et al.
. 2005.
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion.
.
Nature. 438(7064):99-102.
Veazey RS
,
Springer MS
,
Marx PA
,
Dufour J
,
Klasse PJohan
,
Moore JP
. 2005.
Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
.
Nat Med. 11(12):1293-4.
Pejchal R
,
Doores KJ
,
Walker LM
,
Khayat R
,
Huang P-S
,
Wang S-K
,
Stanfield RL
,
Julien J-P
,
Ramos A
,
Crispin M
et al.
. 2011.
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
.
Science. 334(6059):1097-103.
Moore JP
,
Kuritzkes DR
. 2009.
A pièce de resistance: how HIV-1 escapes small molecule CCR5 inhibitors.
.
Curr Opin HIV AIDS. 4(2):118-24.
O
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
N
Dey AK
,
David KB
,
Ray N
,
Ketas TJ
,
Klasse PJ
,
Doms RW
,
Moore JP
. 2008.
N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus.
.
Virology. 372(1):187-200.
Forbes CJ
,
Lowry D
,
Geer L
,
Veazey RS
,
Shattock RJ
,
Klasse PJohan
,
Mitchnick M
,
Goldman L
,
Doyle LA
,
Muldoon BCO
et al.
. 2011.
Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.
.
J Control Release. 156(2):161-9.
Pugach P
,
Ketas TJ
,
Michael E
,
Moore JP
. 2008.
Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors.
.
Virology. 377(2):401-7.
Sanders RW
,
Moore JP
. 2017.
Native-like Env trimers as a platform for HIV-1 vaccine design.
.
Immunol Rev. 275(1):161-182.
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