Native-like Env trimers as a platform for HIV-1 vaccine design.

TitleNative-like Env trimers as a platform for HIV-1 vaccine design.
Publication TypeJournal Article
Year of Publication2017
AuthorsSanders RW, Moore JP
JournalImmunol Rev
Date Published2017 Jan

We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.

Alternate JournalImmunol. Rev.
PubMed ID28133806
PubMed Central IDPMC5299501
Grant List280829 / / European Research Council / International
P01 AI110657 / AI / NIAID NIH HHS / United States

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587