Submitted by mam2155 on March 24, 2014 - 4:19pm
| Title | Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Veazey RS, Springer MS, Marx PA, Dufour J, Klasse PJohan, Moore JP |
| Journal | Nat Med |
| Volume | 11 |
| Issue | 12 |
| Pagination | 1293-4 |
| Date Published | 2005 Dec |
| ISSN | 1078-8956 |
| Keywords | Administration, Oral, Animals, Female, Macaca, Pyrazoles, Receptors, CCR5, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus, Time Factors, Vagina, Valine, Viral Load |
| Abstract | Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection. |
| DOI | 10.1038/nm1321 |
| Alternate Journal | Nat. Med. |
| PubMed ID | 16273102 |