For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit VaccineTogetherNY.org.

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.

TitleProtection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
Publication TypeJournal Article
Year of Publication2005
AuthorsVeazey RS, Springer MS, Marx PA, Dufour J, Klasse PJohan, Moore JP
JournalNat Med
Volume11
Issue12
Pagination1293-4
Date Published2005 Dec
ISSN1078-8956
KeywordsAdministration, Oral, Animals, Female, Macaca, Pyrazoles, Receptors, CCR5, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus, Time Factors, Vagina, Valine, Viral Load
Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

DOI10.1038/nm1321
Alternate JournalNat. Med.
PubMed ID16273102

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587