|Title||Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Veazey RS, Springer MS, Marx PA, Dufour J, Klasse PJohan, Moore JP|
|Date Published||2005 Dec|
|Keywords||Administration, Oral, Animals, Female, Macaca, Pyrazoles, Receptors, CCR5, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus, Time Factors, Vagina, Valine, Viral Load|
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
|Alternate Journal||Nat. Med.|