Microbiology and Immunology

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A

Cohn EF, Nathan C, Radzioch D, Yu H, Xiang Z, Ding A. 2006. Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.. J Immunol. 176(2):1185-94.

Vandal OH, Nathan CF, Ehrt S. 2009. Acid resistance in Mycobacterium tuberculosis.. J Bacteriol. 191(15):4714-21.

Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. 2009. Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.. J Bacteriol. 191(2):625-31.

de Carvalho LPedro S, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee K. 2010. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.. Chem Biol. 17(4):323-32.

Nathan C. 2007. Aligning pharmaceutical innovation with medical need.. Nat Med. 13(3):304-8.

MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.. Cell. 81(4):641-50.

Nathan C, Cars O. 2014. Antibiotic resistance--problems, progress, and prospects.. N Engl J Med. 371(19):1761-3.

Nathan C. 2004. Antibiotics at the crossroads.. Nature. 431(7011):899-902.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M et al.. 2018. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.. Proc Natl Acad Sci U S A. 115(29):E6863-E6870.

Yu H, Lupoli TJ, Kovach A, Meng X, Zhao G, Nathan CF, Li H. 2018. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB.. Proc Natl Acad Sci U S A. 115(41):E9560-E9569.

B

Quezada LLopez, Silve S, Kelinske M, Liba A, Gonzalez CDiaz, Kotev M, Goullieux L, Sans S, Roubert C, Lagrange S et al.. 2019. Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.. mBio. 10(4)

Karreci ESula, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T et al.. 2016. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.. Proc Natl Acad Sci U S A. 113(52):E8425-E8432.

C

Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.. Science. 256(5054):225-8.

Nathan C. 2015. Cooperative development of antimicrobials: looking back to look ahead.. Nat Rev Microbiol. 13(10):651-7.

Vandal OH, Gelb MH, Ehrt S, Nathan CF. 2006. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.. Infect Immun. 74(3):1751-6.

D

Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M et al.. 2019. Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in .. ACS Infect Dis. 5(7):1087-1104.

McAulay K, Saito K, Warrier T, Walsh KFrances, Mathurin LDaniel, Royal-Mardi G, Lee MHee, Ocheretina O, Pape JWilliam, Fitzgerald DW et al.. 2018. Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment.. mBio. 9(6)

Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J. 2017. Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.. mBio. 8(5)

Quezada LLopez, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K et al.. 2019. Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating .. ACS Infect Dis. 5(8):1433-1445.

E

Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan C. 2015. E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.. Proc Natl Acad Sci U S A. 112(43):E5834-43.

Zimmerman M, McDonald SL, Ho-Liang H-P, Porubsky P, Nguyen Q, Pharr CW, Perkowski AJ, Smith R, Schoenen FJ, Gold BS et al.. 2019. Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.. J Antibiot (Tokyo). 72(6):469-475.

Mundhra S, Bryk R, Hawryluk N, Zhang T, Jiang X, Nathan C. 2018. Evidence for dispensability of protein kinase R in host control of tuberculosis.. Eur J Immunol. 48(4):612-620.

F

Nathan C. 2012. Fresh approaches to anti-infective therapies.. Sci Transl Med. 4(140):140sr2.

G

Beaulieu AM, Rath P, Imhof M, Siddall ME, Roberts J, Schnappinger D, Nathan CF. 2010. Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.. PLoS One. 5(12):e15120.

I

Gold B, Deng H, Bryk R, Vargas D, Eliezer D, Roberts J, Jiang X, Nathan C. 2008. Identification of a copper-binding metallothionein in pathogenic mycobacteria.. Nat Chem Biol. 4(10):609-16.