Microbiology and Immunology

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Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, J Warren D et al.. 2013. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.. PLoS One. 8(7):e68942.

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Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. 2011. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.. Cell Host Microbe. 9(1):21-31.

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Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S. 2014. Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR et al.. 2016. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.. PLoS Pathog. 12(12):e1006043.

Lee JJin, Lee S-K, Song N, Nathan TO, Swarts BM, Eum S-Y, Ehrt S, Cho S-N, Eoh H. 2019. Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.. Nat Commun. 10(1):2928.

Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C et al.. 2003. Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.. J Exp Med. 198(5):693-704.

Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MAmir, Su H, Trujillo C et al.. 2020. Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.. Antimicrob Agents Chemother. 64(5)

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED et al.. 2015. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.. ACS Chem Biol. 10(2):364-71.

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Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. 2013. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.. J Biol Chem. 288(18):12489-99.

Biswas T, Small J, Vandal O, Odaira T, Deng H, Ehrt S, Tsodikov OV. 2010. Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.. Structure. 18(10):1353-63.

Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR. 2019. Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.. BMC Bioinformatics. 20(1):603.

Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn JA, Schnappinger D, Wilkinson RJ, Young D. 2009. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.. Nat Rev Microbiol. 7(12):845-55.

Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. 2010. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.. PLoS One. 5(12):e15667.

Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D. 2007. Silencing Mycobacterium smegmatis by using tetracycline repressors.. J Bacteriol. 189(13):4614-23.

Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S et al.. 2008. Selective killing of nonreplicating mycobacteria.. Cell Host Microbe. 3(3):137-45.

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Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S. 2009. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.. Cell Host Microbe. 5(1):35-46.

Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1)

Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1):MGM2-0018-2013.

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Nathan C, Calingasan N, Nezezon J, Ding A, M Lucia S, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NSoo et al.. 2005. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.. J Exp Med. 202(9):1163-9.

K Darwin H, Ehrt S, Gutierrez-Ramos J-C, Weich N, Nathan CF. 2003. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.. Science. 302(5652):1963-6.

Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang H-J, Sutphen ML, Weiner DM, Dayao EK et al.. 2019. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.. Nat Commun. 10(1):4970.

Koo M-S, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S et al.. 2011. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.. PLoS One. 6(2):e17091.

Small JL, Park SWoong, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. 2013. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.. mBio. 4(5):e00475-13.