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Found 85 results
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Ehrt, Sabine
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2020
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
Healy C
,
Gouzy A
,
Ehrt S
. 2020.
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.
.
mBio. 11(2)
Gengenbacher M
,
Zimmerman MD
,
Sarathy JP
,
Kaya F
,
Wang H
,
Mina M
,
Carter C
,
Hossen MAmir
,
Su H
,
Trujillo C
et al.
. 2020.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
.
Antimicrob Agents Chemother. 64(5)
2019
Johnson EO
,
LaVerriere E
,
Office E
,
Stanley M
,
Meyer E
,
Kawate T
,
Gomez JE
,
Audette RE
,
Bandyopadhyay N
,
Betancourt N
et al.
. 2019.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
.
Nature. 571(7763):72-78.
Buter J
,
Cheng T-Y
,
Ghanem M
,
Grootemaat AE
,
Raman S
,
Feng X
,
Plantijn AR
,
Ennis T
,
Wang J
,
Cotton RN
et al.
. 2019.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
.
Nat Chem Biol. 15(9):889-899.
Wang R
,
Kreutzfeldt K
,
Botella H
,
Vaubourgeix J
,
Schnappinger D
,
Ehrt S
. 2019.
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
.
Elife. 8
Beites T
,
O'Brien K
,
Tiwari D
,
Engelhart CA
,
Walters S
,
Andrews J
,
Yang H-J
,
Sutphen ML
,
Weiner DM
,
Dayao EK
et al.
. 2019.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
.
Nat Commun. 10(1):4970.
Subramaniyam S
,
DeJesus MA
,
Zaveri A
,
Smith CM
,
Baker RE
,
Ehrt S
,
Schnappinger D
,
Sassetti CM
,
Ioerger TR
. 2019.
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
.
BMC Bioinformatics. 20(1):603.
Lee JJin
,
Lee S-K
,
Song N
,
Nathan TO
,
Swarts BM
,
Eum S-Y
,
Ehrt S
,
Cho S-N
,
Eoh H
. 2019.
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.
.
Nat Commun. 10(1):2928.
2018
Wescott HH
,
Zuniga ES
,
Bajpai A
,
Trujillo C
,
Ehrt S
,
Schnappinger D
,
Roberts DM
,
Parish T
. 2018.
Identification of Enolase as the Target of 2-Aminothiazoles in .
.
Front Microbiol. 9:2542.
Ehrt S
,
Schnappinger D
,
Rhee KY
. 2018.
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.
.
Nat Rev Microbiol. 16(8):496-507.
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
2017
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Botella H
,
Yang G
,
Ouerfelli O
,
Ehrt S
,
Nathan CF
,
Vaubourgeix J
. 2017.
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
.
mBio. 8(5)
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Botella H
,
Vaubourgeix J
,
Lee MHee
,
Song N
,
Xu W
,
Makinoshima H
,
Glickman MS
,
Ehrt S
. 2017.
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
.
EMBO J. 36(4):536-548.
2016
Schnappinger D
,
Ehrt S
. 2016.
A broader spectrum of tuberculosis.
.
Nat Med. 22(10):1076-1077.
Lin K
,
O'Brien KM
,
Trujillo C
,
Wang R
,
Wallach JB
,
Schnappinger D
,
Ehrt S
. 2016.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
.
PLoS Pathog. 12(6):e1005675.
Korte J
,
Alber M
,
Trujillo CM
,
Syson K
,
Koliwer-Brandl H
,
Deenen R
,
Köhrer K
,
DeJesus MA
,
Hartman T
,
Jacobs WR
et al.
. 2016.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
.
PLoS Pathog. 12(12):e1006043.
2015
Schnappinger D
,
O'Brien KM
,
Ehrt S
. 2015.
Construction of conditional knockdown mutants in mycobacteria.
.
Methods Mol Biol. 1285:151-75.
Goodsmith N
,
Guo XV
,
Vandal OH
,
Vaubourgeix J
,
Wang R
,
Botella H
,
Song S
,
Bhatt K
,
Liba A
,
Salgame P
et al.
. 2015.
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
.
PLoS Pathog. 11(2):e1004645.
Zhao N
,
Sun M
,
Burns-Huang K
,
Jiang X
,
Ling Y
,
Darby C
,
Ehrt S
,
Liu G
,
Nathan C
. 2015.
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
.
PLoS One. 10(5):e0126211.
Ehrt S
,
Rhee K
,
Schnappinger D
. 2015.
Mycobacterial genes essential for the pathogen's survival in the host.
.
Immunol Rev. 264(1):319-26.
Zhao N
,
Darby CM
,
Small J
,
Bachovchin DA
,
Jiang X
,
Burns-Huang KE
,
Botella H
,
Ehrt S
,
Boger DL
,
Anderson ED
et al.
. 2015.
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
.
ACS Chem Biol. 10(2):364-71.
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