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Nathan, Carl F
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A
Cohn EF
,
Nathan C
,
Radzioch D
,
Yu H
,
Xiang Z
,
Ding A
. 2006.
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.
.
J Immunol. 176(2):1185-94.
Vandal OH
,
Nathan CF
,
Ehrt S
. 2009.
Acid resistance in Mycobacterium tuberculosis.
.
J Bacteriol. 191(15):4714-21.
Vandal OH
,
Roberts JA
,
Odaira T
,
Schnappinger D
,
Nathan CF
,
Ehrt S
. 2009.
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
.
J Bacteriol. 191(2):625-31.
de Carvalho LPedro S
,
Zhao H
,
Dickinson CE
,
Arango NM
,
Lima CD
,
Fischer SM
,
Ouerfelli O
,
Nathan C
,
Rhee K
. 2010.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
.
Chem Biol. 17(4):323-32.
Nathan C
. 2007.
Aligning pharmaceutical innovation with medical need.
.
Nat Med. 13(3):304-8.
MacMicking JD
,
Nathan C
,
Hom G
,
Chartrain N
,
Fletcher DS
,
Trumbauer M
,
Stevens K
,
Xie QW
,
Sokol K
,
Hutchinson N
. 1995.
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.
.
Cell. 81(4):641-50.
Nathan C
,
Cars O
. 2014.
Antibiotic resistance--problems, progress, and prospects.
.
N Engl J Med. 371(19):1761-3.
Nathan C
. 2004.
Antibiotics at the crossroads.
.
Nature. 431(7011):899-902.
Kirkman LA
,
Zhan W
,
Visone J
,
Dziedziech A
,
Singh PK
,
Fan H
,
Tong X
,
Bruzual I
,
Hara R
,
Kawasaki M
et al.
. 2018.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
.
Proc Natl Acad Sci U S A. 115(29):E6863-E6870.
Yu H
,
Lupoli TJ
,
Kovach A
,
Meng X
,
Zhao G
,
Nathan CF
,
Li H
. 2018.
ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB.
.
Proc Natl Acad Sci U S A. 115(41):E9560-E9569.
B
Quezada LLopez
,
Silve S
,
Kelinske M
,
Liba A
,
Gonzalez CDiaz
,
Kotev M
,
Goullieux L
,
Sans S
,
Roubert C
,
Lagrange S
et al.
. 2019.
Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.
.
mBio. 10(4)
Karreci ESula
,
Fan H
,
Uehara M
,
Mihali AB
,
Singh PK
,
Kurdi AT
,
Solhjou Z
,
Riella LV
,
Ghobrial I
,
Laragione T
et al.
. 2016.
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
.
Proc Natl Acad Sci U S A. 113(52):E8425-E8432.
C
Xie QW
,
Cho HJ
,
Calaycay J
,
Mumford RA
,
Swiderek KM
,
Lee TD
,
Ding A
,
Troso T
,
Nathan C
. 1992.
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
.
Science. 256(5054):225-8.
Nathan C
. 2015.
Cooperative development of antimicrobials: looking back to look ahead.
.
Nat Rev Microbiol. 13(10):651-7.
Vandal OH
,
Gelb MH
,
Ehrt S
,
Nathan CF
. 2006.
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
.
Infect Immun. 74(3):1751-6.
D
Wu J
,
Mu R
,
Sun M
,
Zhao N
,
Pan M
,
Li H
,
Dong Y
,
Sun Z
,
Bai J
,
Hu M
et al.
. 2019.
Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in .
.
ACS Infect Dis. 5(7):1087-1104.
McAulay K
,
Saito K
,
Warrier T
,
Walsh KFrances
,
Mathurin LDaniel
,
Royal-Mardi G
,
Lee MHee
,
Ocheretina O
,
Pape JWilliam
,
Fitzgerald DW
et al.
. 2018.
Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment.
.
mBio. 9(6)
Botella H
,
Yang G
,
Ouerfelli O
,
Ehrt S
,
Nathan CF
,
Vaubourgeix J
. 2017.
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
.
mBio. 8(5)
Quezada LLopez
,
Li K
,
McDonald SL
,
Nguyen Q
,
Perkowski AJ
,
Pharr CW
,
Gold B
,
Roberts J
,
McAulay K
,
Saito K
et al.
. 2019.
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating .
.
ACS Infect Dis. 5(8):1433-1445.
E
Maksymiuk C
,
Balakrishnan A
,
Bryk R
,
Rhee KY
,
Nathan C
. 2015.
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
.
Proc Natl Acad Sci U S A. 112(43):E5834-43.
Zimmerman M
,
McDonald SL
,
Ho-Liang H-P
,
Porubsky P
,
Nguyen Q
,
Pharr CW
,
Perkowski AJ
,
Smith R
,
Schoenen FJ
,
Gold BS
et al.
. 2019.
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.
.
J Antibiot (Tokyo). 72(6):469-475.
Mundhra S
,
Bryk R
,
Hawryluk N
,
Zhang T
,
Jiang X
,
Nathan C
. 2018.
Evidence for dispensability of protein kinase R in host control of tuberculosis.
.
Eur J Immunol. 48(4):612-620.
F
Nathan C
. 2012.
Fresh approaches to anti-infective therapies.
.
Sci Transl Med. 4(140):140sr2.
G
Beaulieu AM
,
Rath P
,
Imhof M
,
Siddall ME
,
Roberts J
,
Schnappinger D
,
Nathan CF
. 2010.
Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.
.
PLoS One. 5(12):e15120.
I
Gold B
,
Deng H
,
Bryk R
,
Vargas D
,
Eliezer D
,
Roberts J
,
Jiang X
,
Nathan C
. 2008.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
.
Nat Chem Biol. 4(10):609-16.
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