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Nathan, Carl F
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Nathan C
. 2015.
What can immunology contribute to the control of the world's leading cause of death from bacterial infection?
Immunol Rev. 264(1):2-5.
T
Zhang L
,
Jiang X
,
Pfau D
,
Ling Y
,
Nathan CF
. 2021.
Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death.
.
J Exp Med. 218(2)
Nathan C
,
Barry CE
. 2015.
TB drug development: immunology at the table.
.
Immunol Rev. 264(1):308-18.
Gold B
,
Nathan C
. 2017.
Targeting Phenotypically Tolerant Mycobacterium tuberculosis.
.
Microbiol Spectr. 5(1)
Zhao N
,
Darby CM
,
Small J
,
Bachovchin DA
,
Jiang X
,
Burns-Huang KE
,
Botella H
,
Ehrt S
,
Boger DL
,
Anderson ED
et al.
. 2015.
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
.
ACS Chem Biol. 10(2):364-71.
Nathan C
. 2009.
Taming tuberculosis: a challenge for science and society.
.
Cell Host Microbe. 5(3):220-4.
S
Santos Rde Luna Al
,
Bai L
,
Singh PK
,
Murakami N
,
Fan H
,
Zhan W
,
Zhu Y
,
Jiang X
,
Zhang K
,
Assker JPierre
et al.
. 2017.
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
.
Nat Commun. 8(1):1692.
Mosior J
,
Bourland R
,
Soma S
,
Nathan C
,
Sacchettini J
. 2019.
Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.
.
Protein Sci.
Zhan W
,
Hsu H-C
,
Morgan T
,
Ouellette T
,
Burns-Huang K
,
Hara R
,
Wright AG
,
Imaeda T
,
Okamoto R
,
Sato K
et al.
. 2019.
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
.
J Med Chem. 62(20):9246-9253.
R
Saito K
,
Warrier T
,
Somersan-Karakaya S
,
Kaminski L
,
Mi J
,
Jiang X
,
Park S
,
Shigyo K
,
Gold B
,
Roberts J
et al.
. 2017.
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
.
Proc Natl Acad Sci U S A. 114(24):E4832-E4840.
Lupoli TJ
,
Fay A
,
Adura C
,
Glickman MS
,
Nathan C
. 2016.
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.
.
Proc Natl Acad Sci U S A. 113(49):E7947-E7956.
Totaro KA
,
Barthelme D
,
Simpson PT
,
Jiang X
,
Lin G
,
Nathan C
,
Sauer RT
,
Sello JK
. 2017.
Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
.
ACS Infect Dis. 3(2):176-181.
P
K Darwin H
,
Ehrt S
,
Gutierrez-Ramos J-C
,
Weich N
,
Nathan CF
. 2003.
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
.
Science. 302(5652):1963-6.
Nathan C
. 2002.
Points of control in inflammation.
.
Nature. 420(6917):846-52.
Bryk R
,
Griffin P
,
Nathan C
. 2000.
Peroxynitrite reductase activity of bacterial peroxiredoxins.
.
Nature. 407(6801):211-5.
O
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
N
Gold B
,
Smith R
,
Nguyen Q
,
Roberts J
,
Ling Y
,
Quezada LLopez
,
Somersan S
,
Warrier T
,
Little D
,
Pingle M
et al.
. 2016.
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.
.
J Med Chem. 59(13):6027-44.
Nathan C
,
Ding A
. 2010.
Nonresolving inflammation.
.
Cell. 140(6):871-82.
Warrier T
,
Kapilashrami K
,
Argyrou A
,
Ioerger TR
,
Little D
,
Murphy KC
,
Nandakumar M
,
Park S
,
Gold B
,
Mi J
et al.
. 2016.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 113(31):E4523-30.
Nathan C
,
Nussenzweig M
,
Pulvirenti T
. 2017.
The new face of JEM.
.
J Exp Med. 214(12):3467.
Nathan C
. 2006.
Neutrophils and immunity: challenges and opportunities.
.
Nat Rev Immunol. 6(3):173-82.
Lin G
,
Chidawanyika T
,
Tsu C
,
Warrier T
,
Vaubourgeix J
,
Blackburn C
,
Gigstad K
,
Sintchak M
,
Dick L
,
Nathan C
. 2013.
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
.
J Am Chem Soc. 135(27):9968-71.
M
Darby CM
,
Venugopal A
,
Ehrt S
,
Nathan CF
. 2011.
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.
.
Tuberculosis (Edinb). 91(5):343-7.
Bryk R
,
Lima CD
,
Erdjument-Bromage H
,
Tempst P
,
Nathan C
. 2002.
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
.
Science. 295(5557):1073-7.
Vandal OH
,
Pierini LM
,
Schnappinger D
,
Nathan CF
,
Ehrt S
. 2008.
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
.
Nat Med. 14(8):849-54.
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