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2020
Weskamp G
,
Tüshaus J
,
Li D
,
Feederle R
,
Maretzky T
,
Swendemann S
,
Falck-Pedersen E
,
McIlwain DR
,
Mak TW
,
Salmon JE
et al.
. 2020.
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
.
J Biol Chem. 295(13):4350-4358.
Matthews KA
,
Senagbe KM
,
Nötzel C
,
Gonzales CA
,
Tong X
,
Rijo-Ferreira F
,
Bhanu NV
,
Miguel-Blanco C
,
Lafuente-Monasterio MJose
,
Garcia BA
et al.
. 2020.
Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases.
.
ACS Infect Dis. 6(5):1058-1075.
Gengenbacher M
,
Zimmerman MD
,
Sarathy JP
,
Kaya F
,
Wang H
,
Mina M
,
Carter C
,
Hossen MAmir
,
Su H
,
Trujillo C
et al.
. 2020.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
.
Antimicrob Agents Chemother. 64(5)
2019
McLean KJarrod
,
Straimer J
,
Hopp CS
,
Vega-Rodriguez J
,
Small-Saunders JL
,
Kanatani S
,
Tripathi A
,
Mlambo G
,
Dumoulin PC
,
Harris CT
et al.
. 2019.
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
.
Sci Rep. 9(1):13131.
McLean KJarrod
,
Straimer J
,
Hopp CS
,
Vega-Rodriguez J
,
Small-Saunders JL
,
Kanatani S
,
Tripathi A
,
Mlambo G
,
Dumoulin PC
,
Harris CT
et al.
. 2019.
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
.
Sci Rep. 9(1):13131.
Zhan W
,
Visone J
,
Ouellette T
,
Harris JC
,
Wang R
,
Zhang H
,
Singh PK
,
Ginn J
,
Sukenick G
,
Wong T-T
et al.
. 2019.
Improvement of Asparagine Ethylenediamines as Anti-malarial -Selective Proteasome Inhibitors.
.
J Med Chem. 62(13):6137-6145.
Wei F
,
Jiang Z
,
Sun H
,
Pu J
,
Sun Y
,
Wang M
,
Tong Q
,
Bi Y
,
Ma X
,
Gao GFu
et al.
. 2019.
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
.
PLoS Pathog. 15(10):e1008062.
Johnson EO
,
LaVerriere E
,
Office E
,
Stanley M
,
Meyer E
,
Kawate T
,
Gomez JE
,
Audette RE
,
Bandyopadhyay N
,
Betancourt N
et al.
. 2019.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
.
Nature. 571(7763):72-78.
Johnson EO
,
LaVerriere E
,
Office E
,
Stanley M
,
Meyer E
,
Kawate T
,
Gomez JE
,
Audette RE
,
Bandyopadhyay N
,
Betancourt N
et al.
. 2019.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
.
Nature. 571(7763):72-78.
Buter J
,
Cheng T-Y
,
Ghanem M
,
Grootemaat AE
,
Raman S
,
Feng X
,
Plantijn AR
,
Ennis T
,
Wang J
,
Cotton RN
et al.
. 2019.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
.
Nat Chem Biol. 15(9):889-899.
Freire DMendes
,
Gutierrez C
,
Garza-Garcia A
,
Grabowska AD
,
Sala AJ
,
Ariyachaokun K
,
Panikova T
,
Beckham KSH
,
Colom A
,
Pogenberg V
et al.
. 2019.
An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
.
Mol Cell. 73(6):1282-1291.e8.
Beites T
,
O'Brien K
,
Tiwari D
,
Engelhart CA
,
Walters S
,
Andrews J
,
Yang H-J
,
Sutphen ML
,
Weiner DM
,
Dayao EK
et al.
. 2019.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
.
Nat Commun. 10(1):4970.
Voshtani R
,
Song M
,
Wang H
,
Li X
,
Zhang W
,
Tavallaie MS
,
Yan W
,
Sun J
,
Wei F
,
Ma X
. 2019.
Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment.
.
Cancer Lett. 465:24-35.
Wang K-J
,
Wang C
,
Dai L-H
,
Yang J
,
Huang H
,
Ma X-J
,
Zhou Z
,
Yang Z-Y
,
Xu W-D
,
Hua M-M
et al.
. 2019.
Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.
.
Clin Cancer Res. 25(3):1070-1086.
2018
Kirkman LA
,
Zhan W
,
Visone J
,
Dziedziech A
,
Singh PK
,
Fan H
,
Tong X
,
Bruzual I
,
Hara R
,
Kawasaki M
et al.
. 2018.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
.
Proc Natl Acad Sci U S A. 115(29):E6863-E6870.
Kirkman LA
,
Zhan W
,
Visone J
,
Dziedziech A
,
Singh PK
,
Fan H
,
Tong X
,
Bruzual I
,
Hara R
,
Kawasaki M
et al.
. 2018.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
.
Proc Natl Acad Sci U S A. 115(29):E6863-E6870.
Wescott HH
,
Zuniga ES
,
Bajpai A
,
Trujillo C
,
Ehrt S
,
Schnappinger D
,
Roberts DM
,
Parish T
. 2018.
Identification of Enolase as the Target of 2-Aminothiazoles in .
.
Front Microbiol. 9:2542.
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
2017
Liao L
,
Song M
,
Li X
,
Tang L
,
Zhang T
,
Zhang L
,
Pan Y
,
Chouchane L
,
Ma X
. 2017.
E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer.
.
Cancer Res. 77(8):2090-2101.
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Totaro KA
,
Barthelme D
,
Simpson PT
,
Jiang X
,
Lin G
,
Nathan C
,
Sauer RT
,
Sello JK
. 2017.
Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
.
ACS Infect Dis. 3(2):176-181.
2016
Zeng H
,
Guo M
,
Zhou T
,
Tan L
,
Chong CNok
,
Zhang T
,
Dong X
,
Xiang JZhaoying
,
Yu AS
,
Yue L
et al.
. 2016.
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.
.
Cell Stem Cell. 19(3):326-40.
Lin K
,
O'Brien KM
,
Trujillo C
,
Wang R
,
Wallach JB
,
Schnappinger D
,
Ehrt S
. 2016.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
.
PLoS Pathog. 12(6):e1005675.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
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