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Found 162 results
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2020
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
Healy C
,
Gouzy A
,
Ehrt S
. 2020.
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.
.
mBio. 11(2)
Gengenbacher M
,
Zimmerman MD
,
Sarathy JP
,
Kaya F
,
Wang H
,
Mina M
,
Carter C
,
Hossen MAmir
,
Su H
,
Trujillo C
et al.
. 2020.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
.
Antimicrob Agents Chemother. 64(5)
2019
Early J
,
Ollinger J
,
Darby C
,
Alling T
,
Mullen S
,
Casey A
,
Gold B
,
Ochoada J
,
Wiernicki T
,
Masquelin T
et al.
. 2019.
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
.
ACS Infect Dis. 5(2):272-280.
Johnson EO
,
LaVerriere E
,
Office E
,
Stanley M
,
Meyer E
,
Kawate T
,
Gomez JE
,
Audette RE
,
Bandyopadhyay N
,
Betancourt N
et al.
. 2019.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
.
Nature. 571(7763):72-78.
Buter J
,
Cheng T-Y
,
Ghanem M
,
Grootemaat AE
,
Raman S
,
Feng X
,
Plantijn AR
,
Ennis T
,
Wang J
,
Cotton RN
et al.
. 2019.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
.
Nat Chem Biol. 15(9):889-899.
Buter J
,
Cheng T-Y
,
Ghanem M
,
Grootemaat AE
,
Raman S
,
Feng X
,
Plantijn AR
,
Ennis T
,
Wang J
,
Cotton RN
et al.
. 2019.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
.
Nat Chem Biol. 15(9):889-899.
Ballinger E
,
Mosior J
,
Hartman T
,
Burns-Huang K
,
Gold B
,
Morris R
,
Goullieux L
,
Blanc I
,
Vaubourgeix J
,
Lagrange S
et al.
. 2019.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
.
Science. 363(6426)
Wang R
,
Kreutzfeldt K
,
Botella H
,
Vaubourgeix J
,
Schnappinger D
,
Ehrt S
. 2019.
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
.
Elife. 8
Beites T
,
O'Brien K
,
Tiwari D
,
Engelhart CA
,
Walters S
,
Andrews J
,
Yang H-J
,
Sutphen ML
,
Weiner DM
,
Dayao EK
et al.
. 2019.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
.
Nat Commun. 10(1):4970.
Beites T
,
O'Brien K
,
Tiwari D
,
Engelhart CA
,
Walters S
,
Andrews J
,
Yang H-J
,
Sutphen ML
,
Weiner DM
,
Dayao EK
et al.
. 2019.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
.
Nat Commun. 10(1):4970.
Bancells C
,
Llorà-Batlle O
,
Poran A
,
Nötzel C
,
Rovira-Graells N
,
Elemento O
,
Kafsack BFC
,
Cortés A
. 2019.
Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum.
.
Nat Microbiol. 4(1):144-154.
Subramaniyam S
,
DeJesus MA
,
Zaveri A
,
Smith CM
,
Baker RE
,
Ehrt S
,
Schnappinger D
,
Sassetti CM
,
Ioerger TR
. 2019.
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
.
BMC Bioinformatics. 20(1):603.
Lee JJin
,
Lee S-K
,
Song N
,
Nathan TO
,
Swarts BM
,
Eum S-Y
,
Ehrt S
,
Cho S-N
,
Eoh H
. 2019.
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.
.
Nat Commun. 10(1):2928.
Lee JJin
,
Lee S-K
,
Song N
,
Nathan TO
,
Swarts BM
,
Eum S-Y
,
Ehrt S
,
Cho S-N
,
Eoh H
. 2019.
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.
.
Nat Commun. 10(1):2928.
Lee JJin
,
Lee S-K
,
Song N
,
Nathan TO
,
Swarts BM
,
Eum S-Y
,
Ehrt S
,
Cho S-N
,
Eoh H
. 2019.
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.
.
Nat Commun. 10(1):2928.
2018
Oh S
,
Park Y
,
Engelhart CA
,
Wallach JB
,
Schnappinger D
,
Arora K
,
Manikkam M
,
Gac B
,
Wang H
,
Murgolo N
et al.
. 2018.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
.
J Med Chem. 61(22):9952-9965.
Wescott HH
,
Zuniga ES
,
Bajpai A
,
Trujillo C
,
Ehrt S
,
Schnappinger D
,
Roberts DM
,
Parish T
. 2018.
Identification of Enolase as the Target of 2-Aminothiazoles in .
.
Front Microbiol. 9:2542.
Ehrt S
,
Schnappinger D
,
Rhee KY
. 2018.
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.
.
Nat Rev Microbiol. 16(8):496-507.
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
2017
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Botella H
,
Yang G
,
Ouerfelli O
,
Ehrt S
,
Nathan CF
,
Vaubourgeix J
. 2017.
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
.
mBio. 8(5)
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