Microbiology and Immunology

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2014
Lue NF, Chan J, Wright WE, Hurwitz J.  2014.  The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.. Nat Commun. 5:5762.
Osborne LC, Monticelli LA, Nice TJ, Sutherland TE, Siracusa MC, Hepworth MR, Tomov VT, Kobuley D, Tran SV, Bittinger K et al..  2014.  Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.. Science. 345(6196):578-82.
Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Di Wu T-, Poincloux R et al..  2014.  Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.. PLoS Pathog. 10(2):e1003928.
Raju RM, Jedrychowski MP, Wei J-R, Pinkham JT, Park AS, O'Brien K, Rehren G, Schnappinger D, Gygi SP, Rubin EJ.  2014.  Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.. PLoS Pathog. 10(3):e1003994.
Kafsack BFC, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA et al..  2014.  A transcriptional switch underlies commitment to sexual development in malaria parasites.. Nature. 507(7491):248-52.
2013
Shi C, Tiwari D, Wilson DJ, Seiler CL, Schnappinger D, Aldrich CC.  2013.  Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.. ACS Med Chem Lett. 4(12)
Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D et al..  2013.  Database resources for the tuberculosis community.. Tuberculosis (Edinb). 93(1):12-7.
Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D et al..  2013.  Database resources for the tuberculosis community.. Tuberculosis (Edinb). 93(1):12-7.
Kim J-H, O'Brien KM, Sharma R, Boshoff HIM, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC et al..  2013.  A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.. Proc Natl Acad Sci U S A. 110(47):19095-100.
Kim J-H, O'Brien KM, Sharma R, Boshoff HIM, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC et al..  2013.  A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.. Proc Natl Acad Sci U S A. 110(47):19095-100.
Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CGK, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M et al..  2013.  Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.. Nature. 504(7478):153-7.
Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CGK, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M et al..  2013.  Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.. Nature. 504(7478):153-7.
Saenz SA, Siracusa MC, Monticelli LA, Ziegler CGK, Kim BS, Brestoff JR, Peterson LW, E Wherry J, Goldrath AW, Bhandoola A et al..  2013.  IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.. J Exp Med. 210(9):1823-37.
Hepworth MR, Monticelli LA, Fung TC, Ziegler CGK, Grunberg S, Sinha R, Mantegazza AR, Ma H-L, Crawford A, Angelosanto JM et al..  2013.  Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.. Nature. 498(7452):113-7.
Sakamoto K, Kim MJeong, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH.  2013.  Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.. Infect Immun. 81(3):764-76.
Lin G, Chidawanyika T, Tsu C, Warrier T, Vaubourgeix J, Blackburn C, Gigstad K, Sintchak M, Dick L, Nathan C.  2013.  N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.. J Am Chem Soc. 135(27):9968-71.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EYoung et al..  2013.  SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.. Cell Rep. 4(5):861-9.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EYoung et al..  2013.  SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.. Cell Rep. 4(5):861-9.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EYoung et al..  2013.  SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.. Cell Rep. 4(5):861-9.
Noti M, Wojno EDTait, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA et al..  2013.  Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.. Nat Med. 19(8):1005-13.
Noti M, Wojno EDTait, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA et al..  2013.  Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.. Nat Med. 19(8):1005-13.
Siracusa MC, Saenz SA, Wojno EDTait, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM et al..  2013.  Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.. Immunity. 39(6):1158-70.
Siracusa MC, Saenz SA, Wojno EDTait, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM et al..  2013.  Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.. Immunity. 39(6):1158-70.
Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, J Warren D et al..  2013.  Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.. PLoS One. 8(7):e68942.
2012
Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J et al..  2012.  Commensal bacteria calibrate the activation threshold of innate antiviral immunity.. Immunity. 37(1):158-70.