Microbiology and Immunology

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2025

Krieger IV, Sukheja P, Yang B, Tang S, Selle D, Woods A, Engelhart C, Kumar P, Harbut MB, Liu D et al.. 2025. SuFEx-based antitubercular compound irreversibly inhibits Pks13.. Nature.

Mostert D, Braun J, Zimmerman MD, Engelhart CA, Berndl S, Quoika PK, Kany AM, Proietto J, Penalva-Lopez S, Wallach JB et al.. 2025. Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly.. Chem Sci. 16(21):9472-9483.

Singh A, Zwerneman LT, Planck K, Kaneko T, Perkowski AJ, Suh CM, Alex A, Bean J, Burns-Huang K, Zhang D et al.. 2025. Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase.. J Med Chem. 68(14):14645-14698.

Singh A, Zwerneman LT, Planck K, Kaneko T, Perkowski AJ, Suh CM, Alex A, Bean J, Burns-Huang K, Zhang D et al.. 2025. Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase.. J Med Chem. 68(14):14645-14698.

Itkin T, Houghton S, Schreiner R, Lin Y, Badwe CR, Voisin V, Murison A, Seyedhassantehrani N, Kaufmann KB, Garcia-Prat L et al.. 2025. Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing.. Nat Immunol. 26(3):378-390.

2024

Klasse PJ. 2024. Fusion peptide-directed antibodies: Humoral armor against HIV-1 infection.. Sci Transl Med. 16(730):eadl2162.

Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al.. 2024. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.

Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al.. 2024. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.

Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al.. 2024. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.

Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al.. 2024. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.

Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al.. 2024. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.

Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al.. 2024. The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.

Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA et al.. 2024. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.. Sci Immunol. 9(98):eadm7097.

Krieger IV, Yalamanchili S, Dickson P, Engelhart CA, Zimmerman MD, Wood J, Clary E, Nguyen J, Thornton N, Centrella PA et al.. 2024. Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.. ACS Infect Dis. 10(5):1561-1575.

Krieger IV, Yalamanchili S, Dickson P, Engelhart CA, Zimmerman MD, Wood J, Clary E, Nguyen J, Thornton N, Centrella PA et al.. 2024. Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.. ACS Infect Dis. 10(5):1561-1575.

Li TMorgan, Zyulina V, Seltzer ES, Dacic M, Chinenov Y, Daamen AR, Veiga KR, Schwartz N, Oliver DJ, Cabahug-Zuckerman P et al.. 2024. The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus.. Elife. 13

Sim JHyun, Bell R, Feng Z, Chyou S, Shipman WD, Kataru RP, Ivashkiv L, Mehrara B, Lu TT. 2024. Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development.. bioRxiv.

Qu D, Ge P, Botella L, Park SWoong, Lee H-N, Thornton N, Bean JM, Krieger IV, Sacchettini JC, Ehrt S et al.. 2024. Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.. Nat Commun. 15(1):4161.

Dupnik K, Rivera VR, Dorvil N, Duffus Y, Akbarnejad H, Gao Y, Liu J, Apollon A, Dumont E, Riviere C et al.. 2024. Potential Utility of C-reactive Protein for Tuberculosis Risk Stratification Among Patients With Non-Meningitic Symptoms at HIV Diagnosis in Low- and Middle-income Countries.. Open Forum Infect Dis. 11(7):ofae356.

Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al.. 2024. Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.

Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al.. 2024. Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.

Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ et al.. 2024. Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.. Cell Chem Biol. 31(4):729-742.e13.

Samuel H, Morillo RCampelo, Kafsack BFC. 2024. Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites.. Pathogens. 13(11)

Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al.. 2024. Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.

Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al.. 2024. Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.