Microbiology and Immunology

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2022
Ottavi S, Scarry SM, Mosior J, Ling Y, Roberts J, Singh A, Zhang D, Goullieux L, Roubert C, Bacqué E et al..  2022.  In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.. J Med Chem. 65(3):1996-2022.
Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al..  2022.  Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.
Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al..  2022.  Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.
Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al..  2022.  Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.
Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al..  2022.  Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.
Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D et al..  2022.  Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.. J Med Chem. 65(9):6903-6925.
Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D et al..  2022.  Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.. J Med Chem. 65(9):6903-6925.
Hodge EA, Naika GS, Kephart SM, Nguyen A, Zhu R, Benhaim MA, Guo W, Moore JP, Hu S-L, Sanders RW et al..  2022.  Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env.. iScience. 25(6):104449.
Benjamin B, Goldgur Y, Jork N, Jessen HJ, Schwer B, Shuman S.  2022.  Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States.. mBio. 13(6):e0308722.
2021
Ketas TJ, Chaturbhuj D, Portillo VMCruz, Francomano E, Golden E, Chandrasekhar S, Debnath G, Díaz-Tapia R, Yasmeen A, Kramer KD et al..  2021.  Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva.. Pathog Immun. 6(1):116-134.
de Melo CSoares, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A et al..  2021.  Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.. J Med Chem. 64(1):719-740.
de Melo CSoares, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A et al..  2021.  Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.. J Med Chem. 64(1):719-740.
Moore JP, Gounder CR.  2021.  Beta testing the monkey model.. Nat Immunol. 22(10):1201-1203.
Pandey S, Singh A, Yang G, d'Andrea FB, Jiang X, Hartman TE, Mosior JW, Bourland R, Gold B, Roberts J et al..  2021.  Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.. Microbiol Spectr. 9(2):e0092821.
Pandey S, Singh A, Yang G, d'Andrea FB, Jiang X, Hartman TE, Mosior JW, Bourland R, Gold B, Roberts J et al..  2021.  Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.. Microbiol Spectr. 9(2):e0092821.
Honjo K, Russell RM, Li R, Liu W, Stoltz R, Tabengwa EM, Hua Y, Prichard L, Kornbrust AN, Sterrett S et al..  2021.  Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency.. Cell Rep Med. 2(1):100164.
Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong T-T, Imaeda T et al..  2021.  Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.. Angew Chem Int Ed Engl. 60(17):9279-9283.
Lee BShi, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMin Sheril, Manimekalai MSony S, Koh VH et al..  2021.  Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.. EMBO Mol Med. 13(1):e13207.
Caniels TG, Bontjer I, van der Straten K, Poniman M, Burger JA, Appelman B, Lavell AHAyesha, Oomen M, Godeke G-J, Valle C et al..  2021.  Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination.. Sci Adv. 7(36):eabj5365.
Caniels TG, Bontjer I, van der Straten K, Poniman M, Burger JA, Appelman B, Lavell AHAyesha, Oomen M, Godeke G-J, Valle C et al..  2021.  Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination.. Sci Adv. 7(36):eabj5365.
Gross MR, Hsu R, Deitsch KW.  2021.  Evolution of transcriptional control of antigenic variation and virulence in human and ape malaria parasites.. BMC Ecol Evol. 21(1):139.
Wipperman MF, Bhattarai SK, Vorkas CKyriakos, Maringati VSuhas, Taur Y, Mathurin L, McAulay K, Vilbrun SCharles, Francois D, Bean J et al..  2021.  Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis.. Nat Commun. 12(1):1141.
Schwer B, Garg A, Jacewicz A, Shuman S.  2021.  Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.. Proc Natl Acad Sci U S A. 118(33)
Gouzy A, Healy C, Black KA, Rhee KY, Ehrt S.  2021.  Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.. Proc Natl Acad Sci U S A. 118(32)
Zhang H, Hsu H-C, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R et al..  2021.  Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.. J Med Chem. 64(9):6262-6272.