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2025
Bond AN, Orzechowski M, Zhang S, Ben-Zion I, Lemmer A, Garry N, Lee K, Chen M, Delano K, Gath E et al..  2025.  Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.. Nat Commun. 16(1):9673.
Kent A, Mon KJoy Yee, Hutchins Z, Putzel G, Zhigarev D, Grier A, Jia B, Kortlever RM, Barbet G, Evan GI et al..  2025.  A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis.. Nat Immunol. 26(1):53-67.
Krieger IV, Sukheja P, Yang B, Tang S, Selle D, Woods A, Engelhart C, Kumar P, Harbut MB, Liu D et al..  2025.  SuFEx-based antitubercular compound irreversibly inhibits Pks13.. Nature.
Mostert D, Braun J, Zimmerman MD, Engelhart CA, Berndl S, Quoika PK, Kany AM, Proietto J, Penalva-Lopez S, Wallach JB et al..  2025.  Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly.. Chem Sci. 16(21):9472-9483.
2024
Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al..  2024.  The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA et al..  2024.  Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.. Sci Immunol. 9(98):eadm7097.
Krieger IV, Yalamanchili S, Dickson P, Engelhart CA, Zimmerman MD, Wood J, Clary E, Nguyen J, Thornton N, Centrella PA et al..  2024.  Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.. ACS Infect Dis. 10(5):1561-1575.
Miller AH, Marks F, Chan L, Botella H, Schnappinger D, Ehrt S.  2024.  Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in Mycobacterium smegmatis.. Microbiol Spectr. 12(7):e0048724.
Qu D, Ge P, Botella L, Park SWoong, Lee H-N, Thornton N, Bean JM, Krieger IV, Sacchettini JC, Ehrt S et al..  2024.  Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.. Nat Commun. 15(1):4161.
Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ et al..  2024.  Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.. Cell Chem Biol. 31(4):729-742.e13.
Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al..  2024.  Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.
Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al..  2024.  Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.
Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al..  2024.  Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.
Hahn WO, K Parks R, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Davis ASWoodward, Duplessis C, Tomai M, Dey AK et al..  2024.  Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies.. J Exp Med. 221(10)
2023
Wong AI, Beites T, Planck KA, Fieweger RA, Eckartt KA, Li S, Poulton NC, VanderVen BC, Rhee KY, Schnappinger D et al..  2023.  Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis.. Elife. 12
Wong AI, Beites T, Planck KA, Fieweger RA, Eckartt KA, Li S, Poulton NC, VanderVen BC, Rhee KY, Schnappinger D et al..  2023.  Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis.. Elife. 12
de Miranda R, Cuthbert BJ, Klevorn T, Chao A, Mendoza J, Arbing M, Sieminski PJ, Papavinasasundaram K, Abdul-Hafiz S, Chan S et al..  2023.  Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake.. PLoS Pathog. 19(9):e1011650.
Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al..  2023.  Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.
Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al..  2023.  Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.
Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al..  2023.  Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.
Prabhu M, Yang YJ, Johnston CD, Murphy EA, Ketas TJ, Díaz-Tapia R, Jurkiewicz M, Racine-Brzostek S, Mohammed I, Sukhu AC et al..  2023.  Longitudinal antibody response kinetics following SARS-CoV-2 messenger RNA vaccination in pregnant and nonpregnant persons.. Am J Obstet Gynecol MFM. 5(2):100796.
Sharma R, Hartman TE, Beites T, Kim J-H, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S et al..  2023.  Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis.. mBio. 14(4):e0034023.
Sharma R, Hartman TE, Beites T, Kim J-H, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S et al..  2023.  Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis.. mBio. 14(4):e0034023.
Sharma R, Hartman TE, Beites T, Kim J-H, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S et al..  2023.  Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis.. mBio. 14(4):e0034023.
Hegde P, Orimoloye MO, Sharma S, Engelhart CA, Schnappinger D, Aldrich CC.  2023.  Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis.. Tuberculosis (Edinb). 140:102346.