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Microbiology and Immunology

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Vive la Différence: Exploiting the Differences between Rodent and Human Malarias.

TitleVive la Différence: Exploiting the Differences between Rodent and Human Malarias.
Publication TypeJournal Article
Year of Publication2020
AuthorsKirkman LA, Deitsch KW
JournalTrends Parasitol
Volume36
Issue6
Pagination504-511
Date Published2020 Jun
ISSN1471-5007
Abstract

Experimental research into malaria biology and pathogenesis has historically focused on two model systems, in vitro culture of the human parasite Plasmodium falciparum and in vivo infections of laboratory animals using rodent parasites. While there is clear value in having a manipulatable animal model for studying malaria, there have occasionally been controversies around how representative the rodent model is of the human disease, and therefore significant emphasis has been placed on the similarities between the two biological systems. By focusing on basic nuclear functions, we wish to highlight that identifying key differences in the parasites and their interactions with their mammalian hosts can be equally informative and provide remarkable insights into the biology and evolution of these important infectious organisms.

DOI10.1016/j.pt.2020.03.008
Alternate JournalTrends Parasitol
PubMed ID32407681
PubMed Central IDPMC7229027
Grant ListK08 AI076635 / AI / NIAID NIH HHS / United States
R01 AI052390 / AI / NIAID NIH HHS / United States
R01 AI099327 / AI / NIAID NIH HHS / United States
R01 AI146153 / AI / NIAID NIH HHS / United States

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