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Visceral Leishmania donovani infection in interleukin-13-/- mice.

TitleVisceral Leishmania donovani infection in interleukin-13-/- mice.
Publication TypeJournal Article
Year of Publication2006
AuthorsMurray HW, Tsai CW, Liu J, Ma X
JournalInfect Immun
Volume74
Issue4
Pagination2487-90
Date Published2006 Apr
ISSN0019-9567
KeywordsAnimals, Cytokines, Immunity, Innate, Interleukin-13, Leishmania donovani, Leishmaniasis, Visceral, Liver Diseases, Parasitic, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout
Abstract

Leishmania donovani-infected interleukin-13-/- BALB/c mice showed impaired initial gamma interferon secretion and incomplete granuloma assembly at parasitized liver foci. Nonetheless, control of early parasite replication, resolution of liver infection, and responsiveness to antileishmanial chemotherapy were intact. By itself, interleukin-13 does not appear to materially influence acquired resistance in this intracellular infection.

DOI10.1128/IAI.74.4.2487-2490.2006
Alternate JournalInfect Immun
PubMed ID16552085
PubMed Central IDPMC1418934
Grant ListR01 AI045899 / AI / NIAID NIH HHS / United States
AI 16369 / AI / NIAID NIH HHS / United States
AI 45899 / AI / NIAID NIH HHS / United States

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