Submitted by mam2155 on March 24, 2014 - 4:11pm
| Title | varDB: common ground for a shifting landscape. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Allred DR, Barbet AF, J Barry D, Deitsch KW |
| Journal | Trends Parasitol |
| Volume | 25 |
| Issue | 6 |
| Pagination | 249-52 |
| Date Published | 2009 Jun |
| ISSN | 1471-5007 |
| Keywords | Animals, Antigenic Variation, Bacteria, Databases, Genetic, Databases, Protein, Eukaryota, Fungi, HIV, Humans, Proteins, Structure-Activity Relationship |
| Abstract | Antigenic variation is a phylogenetically widespread phenomenon thought to lead to survival benefits for the pathogen. Although governed by genetic mechanisms, antigenic variation is ultimately manifested in variant proteins. The varDB database is an attempt to gain an overview of common structures and functions of variant proteins related to enhanced survival. varDB provides a wealth of sequence data and several tools to facilitate their analysis, but current limitations preclude achievement of its full promise. A critique of this database and how it could serve the scientific community is provided here. |
| DOI | 10.1016/j.pt.2009.03.003 |
| Alternate Journal | Trends Parasitol |
| PubMed ID | 19423393 |
| PubMed Central ID | PMC3697053 |
| Grant List | R01 AI052390 / AI / NIAID NIH HHS / United States R01 AI055864 / AI / NIAID NIH HHS / United States R01 GM081714 / GM / NIGMS NIH HHS / United States |