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TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.

TitleTSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.
Publication TypeJournal Article
Year of Publication2013
AuthorsKim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Hepworth MR, Van Voorhees AS, Comeau MR, Artis D
JournalSci Transl Med
Volume5
Issue170
Pagination170ra16
Date Published2013 Jan 30
ISSN1946-6242
KeywordsAdaptive Immunity, Animals, Cytokines, Dermatitis, Atopic, Disease Models, Animal, Humans, Immunity, Innate, Inflammation, Interleukins, Lymphocytes, Mice, Mice, Inbred C57BL, Protein Binding, Skin
Abstract

Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells that can be divided into three groups based on their differential developmental requirements and expression of effector cytokines. Among these, group 2 ILCs produce the type 2 cytokines interleukin-5 (IL-5) and IL-13 and promote type 2 inflammation in the lung and intestine. However, whether group 2 ILCs reside in the skin and contribute to skin inflammation has not been characterized. We identify a population of skin-resident group 2 ILCs present in healthy human skin that are enriched in lesional human skin from atopic dermatitis (AD) patients. Group 2 ILCs were also found in normal murine skin and were critical for the development of inflammation in a murine model of AD-like disease. Remarkably, in contrast to group 2 ILC responses in the intestine and lung, which are critically regulated by IL-33 and IL-25, group 2 ILC responses in the skin and skin-draining lymph nodes were independent of these canonical cytokines but were critically dependent on thymic stromal lymphopoietin (TSLP). Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation.

DOI10.1126/scitranslmed.3005374
Alternate JournalSci Transl Med
PubMed ID23363980
PubMed Central IDPMC3637661
Grant List2-P30 CA016520 / CA / NCI NIH HHS / United States
5-P30-AR-057217 / AR / NIAMS NIH HHS / United States
AI061570 / AI / NIAID NIH HHS / United States
AI074878 / AI / NIAID NIH HHS / United States
AI083480 / AI / NIAID NIH HHS / United States
AI085828 / AI / NIAID NIH HHS / United States
AI087990 / AI / NIAID NIH HHS / United States
AI095466 / AI / NIAID NIH HHS / United States
AI095608 / AI / NIAID NIH HHS / United States
AI097333 / AI / NIAID NIH HHS / United States
AI102942 / AI / NIAID NIH HHS / United States
DP5 OD012116 / OD / NIH HHS / United States
DP5OD012116 / OD / NIH HHS / United States
KL2 TR000139 / TR / NCATS NIH HHS / United States
KL2-RR024132 / RR / NCRR NIH HHS / United States
KL2TR000139 / TR / NCATS NIH HHS / United States
P30 AR057217 / AR / NIAMS NIH HHS / United States
P30 CA016520 / CA / NCI NIH HHS / United States
P30-DK050306 / DK / NIDDK NIH HHS / United States
R01 AI061570 / AI / NIAID NIH HHS / United States
R01 AI074878 / AI / NIAID NIH HHS / United States
R01 AI095466 / AI / NIAID NIH HHS / United States
R01 AI097333 / AI / NIAID NIH HHS / United States
R01 AI102942 / AI / NIAID NIH HHS / United States
R21 AI083480 / AI / NIAID NIH HHS / United States
R21 AI087990 / AI / NIAID NIH HHS / United States
T32 AI007532 / AI / NIAID NIH HHS / United States
T32-AI007532 / AI / NIAID NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States

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