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Towards understanding the extreme radiation resistance of Ustilago maydis.

TitleTowards understanding the extreme radiation resistance of Ustilago maydis.
Publication TypeJournal Article
Year of Publication2007
AuthorsHolloman WK, Schirawski J, Holliday R
JournalTrends Microbiol
Volume15
Issue12
Pagination525-9
Date Published2007 Dec
ISSN0966-842X
KeywordsAnimals, Biological Evolution, Deinococcus, DNA Repair, DNA Repair Enzymes, Radiation Tolerance, Radiation, Ionizing, Recombination, Genetic, Ultraviolet Rays, Ustilago
Abstract

Ustilago maydis is a phytopathogenic fungus exhibiting extreme resistance to UV and ionizing radiation. The molecular mechanisms underlying this resistance are as yet unknown. The recently determined genome sequence was examined for clues to the radiation resistance, focusing on proteins in homologous recombination, but there was little that was unusual about them. Furthermore, by comparison, its recombinational repair system seems to be only minimally related to the extended synthesis-dependent DNA strand-annealing system of Deinococcus radiodurans. Thus, consideration should be given to the possibility that incremental structural changes in repair proteins or their elevated expression are the basis for the extreme radiation resistance in U. maydis. Evolution of a system enabling the survival of U. maydis under such conditions could be a secondary consequence of adaptation to an environment of continual genotoxic stress encountered in its habitat.

DOI10.1016/j.tim.2007.10.007
Alternate JournalTrends Microbiol.
PubMed ID17997098
Grant ListGM42482 / GM / NIGMS NIH HHS / United States
GM79859 / GM / NIGMS NIH HHS / United States

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