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TNF-alpha and IL-12: a balancing act in macrophage functioning.

TitleTNF-alpha and IL-12: a balancing act in macrophage functioning.
Publication TypeJournal Article
Year of Publication2001
AuthorsMa X
JournalMicrobes Infect
Volume3
Issue2
Pagination121-9
Date Published2001 Feb
ISSN1286-4579
KeywordsAnimals, Humans, Immunity, Cellular, Immunity, Innate, Inflammation, Interleukin-12, Macrophages, Mice, Tumor Necrosis Factor-alpha
Abstract

Tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) are two major macrophage-derived mediators of inflammatory responses in mammals. Increasing evidence suggests that TNF-alpha is a double-edged sword with both proinflammatory and anti-inflammatory propensities. This article discusses the inter-regulation of TNF-alpha and IL-12 and the impact on the function of macrophages in innate and adaptive immunity.

DOI10.1016/s1286-4579(00)01359-9
Alternate JournalMicrobes Infect
PubMed ID11251298
Grant ListAI45899 / AI / NIAID NIH HHS / United States
CA79772 / CA / NCI NIH HHS / United States

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