Submitted by mam2155 on March 24, 2014 - 4:16pm
| Title | TNF-alpha and IL-12: a balancing act in macrophage functioning. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Ma X |
| Journal | Microbes Infect |
| Volume | 3 |
| Issue | 2 |
| Pagination | 121-9 |
| Date Published | 2001 Feb |
| ISSN | 1286-4579 |
| Keywords | Animals, Humans, Immunity, Cellular, Immunity, Innate, Inflammation, Interleukin-12, Macrophages, Mice, Tumor Necrosis Factor-alpha |
| Abstract | Tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) are two major macrophage-derived mediators of inflammatory responses in mammals. Increasing evidence suggests that TNF-alpha is a double-edged sword with both proinflammatory and anti-inflammatory propensities. This article discusses the inter-regulation of TNF-alpha and IL-12 and the impact on the function of macrophages in innate and adaptive immunity. |
| DOI | 10.1016/s1286-4579(00)01359-9 |
| Alternate Journal | Microbes Infect |
| PubMed ID | 11251298 |
| Grant List | AI45899 / AI / NIAID NIH HHS / United States CA79772 / CA / NCI NIH HHS / United States |