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Tetracyclines: antibiotic action, uptake, and resistance mechanisms.

TitleTetracyclines: antibiotic action, uptake, and resistance mechanisms.
Publication TypeJournal Article
Year of Publication1996
AuthorsSchnappinger D, Hillen W
JournalArch Microbiol
Volume165
Issue6
Pagination359-69
Date Published1996 Jun
ISSN0302-8933
KeywordsEscherichia coli, Ribosomes, Tetracycline Resistance, Tetracyclines
Abstract

Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline. The two widespread mechanisms of bacterial resistance do not destroy tetracycline: one is mediated by efflux pumps, the other involves an EF-G-like protein that confers ribosome protection. Oxidative destruction of tetracycline has been found in a few species. Several efflux transporters, including multidrug-resistance pumps and tetracycline-specific exporters, confer bacterial resistance against tetracycline. Single amino acids of these carrier proteins important for tetracycline transport and substrate specificity have been identified, allowing the mechanism of tetracycline transport to begin to emerge.

DOI10.1007/s002030050339
Alternate JournalArch Microbiol
PubMed ID8661929

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