For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit VaccineTogetherNY.org.

Targeting malaria parasite proteins to the erythrocyte.

TitleTargeting malaria parasite proteins to the erythrocyte.
Publication TypeJournal Article
Year of Publication2005
AuthorsTempleton TJ, Deitsch KW
JournalTrends Parasitol
Volume21
Issue9
Pagination399-402
Date Published2005 Sep
ISSN1471-4922
KeywordsAmino Acid Sequence, Animals, Erythrocytes, Genes, Protozoan, Host-Parasite Interactions, Humans, Malaria, Falciparum, Plasmodium falciparum, Protozoan Proteins, Sequence Alignment, Vacuoles
Abstract

The intraerythrocytic stages of the protozoan parasite Plasmodium falciparum reside within a parasitophorous vacuole (PV) and set up unique "extraparasite, intraerythrocyte" protein-trafficking pathways that target parasite-encoded proteins to the erythrocyte cytoplasm and cell surface. Two recent articles report the identification of trafficking motifs that regulate the transport of parasite-encoded proteins across the PV. These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane.

DOI10.1016/j.pt.2005.07.006
Alternate JournalTrends Parasitol
PubMed ID16046185

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587