Targeting malaria parasite proteins to the erythrocyte.

TitleTargeting malaria parasite proteins to the erythrocyte.
Publication TypeJournal Article
Year of Publication2005
AuthorsTempleton TJ, Deitsch KW
JournalTrends Parasitol
Date Published2005 Sep
KeywordsAmino Acid Sequence, Animals, Erythrocytes, Genes, Protozoan, Host-Parasite Interactions, Humans, Malaria, Falciparum, Plasmodium falciparum, Protozoan Proteins, Sequence Alignment, Vacuoles

The intraerythrocytic stages of the protozoan parasite Plasmodium falciparum reside within a parasitophorous vacuole (PV) and set up unique "extraparasite, intraerythrocyte" protein-trafficking pathways that target parasite-encoded proteins to the erythrocyte cytoplasm and cell surface. Two recent articles report the identification of trafficking motifs that regulate the transport of parasite-encoded proteins across the PV. These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane.

Alternate JournalTrends Parasitol
PubMed ID16046185

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