Targeting malaria parasite proteins to the erythrocyte.

TitleTargeting malaria parasite proteins to the erythrocyte.
Publication TypeJournal Article
Year of Publication2005
AuthorsTempleton TJ, Deitsch KW
JournalTrends Parasitol
Volume21
Issue9
Pagination399-402
Date Published2005 Sep
ISSN1471-4922
KeywordsAmino Acid Sequence, Animals, Erythrocytes, Genes, Protozoan, Host-Parasite Interactions, Humans, Malaria, Falciparum, Plasmodium falciparum, Protozoan Proteins, Sequence Alignment, Vacuoles
Abstract

The intraerythrocytic stages of the protozoan parasite Plasmodium falciparum reside within a parasitophorous vacuole (PV) and set up unique "extraparasite, intraerythrocyte" protein-trafficking pathways that target parasite-encoded proteins to the erythrocyte cytoplasm and cell surface. Two recent articles report the identification of trafficking motifs that regulate the transport of parasite-encoded proteins across the PV. These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane.

DOI10.1016/j.pt.2005.07.006
Alternate JournalTrends Parasitol
PubMed ID16046185

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