Submitted by mam2155 on March 24, 2014 - 4:11pm
| Title | A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Gannoun-Zaki L, Jost A, Mu J, Deitsch KW, Wellems TE |
| Journal | Eukaryot Cell |
| Volume | 4 |
| Issue | 2 |
| Pagination | 490-2 |
| Date Published | 2005 Feb |
| ISSN | 1535-9778 |
| Keywords | Animals, Gene Deletion, Gene Expression Regulation, Gene Silencing, Genes, Reporter, Introns, Plasmids, Plasmodium falciparum, Promoter Regions, Genetic |
| Abstract | Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes. |
| DOI | 10.1128/EC.4.2.490-492.2005 |
| Alternate Journal | Eukaryot Cell |
| PubMed ID | 15701812 |
| PubMed Central ID | PMC549332 |