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A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.

TitleA silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.
Publication TypeJournal Article
Year of Publication2005
AuthorsGannoun-Zaki L, Jost A, Mu J, Deitsch KW, Wellems TE
JournalEukaryot Cell
Volume4
Issue2
Pagination490-2
Date Published2005 Feb
ISSN1535-9778
KeywordsAnimals, Gene Deletion, Gene Expression Regulation, Gene Silencing, Genes, Reporter, Introns, Plasmids, Plasmodium falciparum, Promoter Regions, Genetic
Abstract

Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.

DOI10.1128/EC.4.2.490-492.2005
Alternate JournalEukaryot Cell
PubMed ID15701812
PubMed Central IDPMC549332

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