Submitted by ljc4002 on March 2, 2026 - 10:44am
| Title | Shifting metabolism alters rRNA expression in malaria parasites. |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Hadjimichael E, Deitsch KW |
| Journal | Trends Parasitol |
| Date Published | 2026 Feb 24 |
| ISSN | 1471-5007 |
| Abstract | Malaria parasites display the unique property of expressing distinct ribosomal RNAs at different points in their transmission cycle. Couble et al. determined that derepression of the mosquito-specific rDNA loci is initiated by altered NAD+/nicotinamide (NAM) ratios, resulting from the metabolic shift that parasites undergo as they transition into the mosquito stages. |
| DOI | 10.1016/j.pt.2026.01.014 |
| Alternate Journal | Trends Parasitol |
| PubMed ID | 41741251 |