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A sequence-ready map of the human chromosome 17p telomere.

TitleA sequence-ready map of the human chromosome 17p telomere.
Publication TypeJournal Article
Year of Publication1999
AuthorsXiang Z, Hu XL, Flint J, Riethman HC
JournalGenomics
Volume58
Issue2
Pagination207-10
Date Published1999 Jun 1
ISSN0888-7543
KeywordsChromosome Mapping, Chromosomes, Artificial, Yeast, Chromosomes, Human, Pair 17, Contig Mapping, Cosmids, Endonucleases, Humans, Models, Genetic, Molecular Sequence Data, Rec A Recombinases, Telomere
Abstract

A half-YAC clone derived from human chromosome 17p was mapped at high resolution using cosmid subclone fingerprint analysis. Colinearity of the half-YAC with the telomeric human genomic DNA fragment was ascertained by RecA-assisted restriction endonuclease cleavage mapping. Previously isolated and radiation hybrid-mapped markers TEL17P37, TEL17P49, and TEL17P80 mapped 30-60 kb from the 17p terminus. This sequence-ready map permits high-resolution integration of genetic maps with the DNA sequences directly adjacent to the tip of human chromosome 17p, and will provide the cloned DNA required for ascertaining the nucleotide sequence of this subtelomeric region.

DOI10.1006/geno.1999.5826
Alternate JournalGenomics
PubMed ID10366453
Grant ListHG00567 / HG / NHGRI NIH HHS / United States
/ / Wellcome Trust / United Kingdom

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