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Sensing danger through a "finger".

TitleSensing danger through a "finger".
Publication TypeJournal Article
Year of Publication2018
AuthorsMa X
JournalJ Exp Med
Volume215
Issue12
Pagination2969-2971
Date Published2018 12 03
ISSN1540-9538
KeywordsInterleukin-12, Protein Transport, Signal Transduction, Transcription Factors, Transcription, Genetic
Abstract

In this issue of , the study by Chen et al. (https://doi.org/10.1084/jem.20181031) reveals a previously unrecognized role of cellular nucleic acid-binding protein (Cnbp) as a novel transcriptional regulator of interleukin-12β (IL-12β) transcription and IL-12-driven, Th1-mediated immune responses, which has important implications for both host defense and inflammatory disease.

DOI10.1084/jem.20182034
Alternate JournalJ Exp Med
PubMed ID30459157
PubMed Central IDPMC6279409

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