Submitted by mam2155 on March 24, 2014 - 4:16pm
| Title | Role of Nod2 in the development of Crohn's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Yamamoto S, Ma X |
| Journal | Microbes Infect |
| Volume | 11 |
| Issue | 12 |
| Pagination | 912-8 |
| Date Published | 2009 Oct |
| ISSN | 1769-714X |
| Keywords | Crohn Disease, Cytokines, Humans, Inflammation, Macrophages, Models, Biological, Monocytes, Mutant Proteins, Nod2 Signaling Adaptor Protein |
| Abstract | Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process. |
| DOI | 10.1016/j.micinf.2009.06.005 |
| Alternate Journal | Microbes Infect |
| PubMed ID | 19573617 |
| PubMed Central ID | PMC2924159 |
| Grant List | R01 AI072149 / AI / NIAID NIH HHS / United States R01 AI072149-01A2 / AI / NIAID NIH HHS / United States R01 AI072149-01A2S1 / AI / NIAID NIH HHS / United States |