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Role of Nod2 in the development of Crohn's disease.

TitleRole of Nod2 in the development of Crohn's disease.
Publication TypeJournal Article
Year of Publication2009
AuthorsYamamoto S, Ma X
JournalMicrobes Infect
Volume11
Issue12
Pagination912-8
Date Published2009 Oct
ISSN1769-714X
KeywordsCrohn Disease, Cytokines, Humans, Inflammation, Macrophages, Models, Biological, Monocytes, Mutant Proteins, Nod2 Signaling Adaptor Protein
Abstract

Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.

DOI10.1016/j.micinf.2009.06.005
Alternate JournalMicrobes Infect
PubMed ID19573617
PubMed Central IDPMC2924159
Grant ListR01 AI072149 / AI / NIAID NIH HHS / United States
R01 AI072149-01A2 / AI / NIAID NIH HHS / United States
R01 AI072149-01A2S1 / AI / NIAID NIH HHS / United States

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