Submitted by mam2155 on March 24, 2014 - 4:16pm
| Title | Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Murray HW, Tsai CW, Liu J, Ma X |
| Journal | Infect Immun |
| Volume | 74 |
| Issue | 7 |
| Pagination | 4370-4 |
| Date Published | 2006 Jul |
| ISSN | 0019-9567 |
| Keywords | Animals, Female, Genetic Predisposition to Disease, Immunity, Innate, Interferon-gamma, Interleukin-12, Interleukin-18, Interleukin-23, Interleukin-23 Subunit p19, Interleukins, Leishmania donovani, Leishmaniasis, Visceral, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout |
| Abstract | Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12. |
| DOI | 10.1128/IAI.00422-06 |
| Alternate Journal | Infect Immun |
| PubMed ID | 16790814 |
| PubMed Central ID | PMC1489747 |
| Grant List | R01 AI045899 / AI / NIAID NIH HHS / United States AI 16369 / AI / NIAID NIH HHS / United States AI 45899 / AI / NIAID NIH HHS / United States |