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Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase.

TitleResponses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase.
Publication TypeJournal Article
Year of Publication2006
AuthorsMurray HW, Xiang Z, Ma X
JournalAm J Trop Med Hyg
Volume74
Issue6
Pagination1013-5
Date Published2006 Jun
ISSN0002-9637
KeywordsAmphotericin B, Animals, Antimony Sodium Gluconate, Antiprotozoal Agents, Gene Expression Profiling, Granuloma, Foreign-Body, GTP Phosphohydrolases, Leishmania donovani, Leishmaniasis, Visceral, Liver, Macrophages, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Nitric Oxide Synthase Type II, Oxidoreductases, Phagocytes, Spleen
Abstract

Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained Leishmania donovani visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by L. donovani, emerges after chemotherapy.

Alternate JournalAm J Trop Med Hyg
PubMed ID16760512
Grant ListAI016393 / AI / NIAID NIH HHS / United States
AI45899 / AI / NIAID NIH HHS / United States

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