Submitted by mam2155 on March 24, 2014 - 4:16pm
| Title | Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Murray HW, Xiang Z, Ma X |
| Journal | Am J Trop Med Hyg |
| Volume | 74 |
| Issue | 6 |
| Pagination | 1013-5 |
| Date Published | 2006 Jun |
| ISSN | 0002-9637 |
| Keywords | Amphotericin B, Animals, Antimony Sodium Gluconate, Antiprotozoal Agents, Gene Expression Profiling, Granuloma, Foreign-Body, GTP Phosphohydrolases, Leishmania donovani, Leishmaniasis, Visceral, Liver, Macrophages, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Nitric Oxide Synthase Type II, Oxidoreductases, Phagocytes, Spleen |
| Abstract | Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained Leishmania donovani visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by L. donovani, emerges after chemotherapy. |
| Alternate Journal | Am J Trop Med Hyg |
| PubMed ID | 16760512 |
| Grant List | AI016393 / AI / NIAID NIH HHS / United States AI45899 / AI / NIAID NIH HHS / United States |