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Resolving resolvases: the final act?

TitleResolving resolvases: the final act?
Publication TypeJournal Article
Year of Publication2008
AuthorsSymington LS, Holloman WK
JournalMol Cell
Volume32
Issue5
Pagination603-4
Date Published2008 Dec 5
ISSN1097-4164
KeywordsDNA, Cruciform, HeLa Cells, Humans, Recombinases, Saccharomyces cerevisiae
Abstract

The Holliday junction (HJ) is a central intermediate in homologous recombination. Ip et al. (2008), in a recent issue of Nature, have identified a new subclass of the Rad2/XPG family of nucleases with the hallmark of symmetrical cleavage of HJ substrates to produce nicked duplex products.

DOI10.1016/j.molcel.2008.11.011
Alternate JournalMol. Cell
PubMed ID19061635
Grant ListR01 GM041784-20 / GM / NIGMS NIH HHS / United States
R01 GM042482 / GM / NIGMS NIH HHS / United States

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